SCHEMBL11568593

SCHEMBL11568593

COC(=O)C(Oc1ccc(Cl)c(Cl)c1)c1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.46
F9 P00740 1/20 0.44
F10 P00742 1/20 0.44
SLC6A3 Q01959 8/20 0.44
MEN1 O00255 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PPARG P37231 5/20 0.41
SLC22A12 Q96S37 1/20 0.41
SLC6A2 P23975 2/20 0.41
SLC6A4 P31645 2/20 0.41
FNTA P49354 2/20 0.40
FNTB P49356 2/20 0.40
KMO O15229 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11560044 0.91 F9 (0.44) FFAR1F9F10MEN1MAPT
SCHEMBL11565422 0.90 F9 (0.46) F9F10MEN1MAPTKMT2A
SCHEMBL11569905 0.90 F9 (0.43) F9F10MEN1MAPTKMT2A
SCHEMBL11638373 0.88 F9 (0.45) F9F10L3MBTL1PPARGSLC22A12
SCHEMBL11566529 0.85 F9 (0.44) F9F10MEN1KMT2AL3MBTL1
SCHEMBL11566988 0.85 F9 (0.51) F9F10MEN1KMT2AL3MBTL1
SCHEMBL11564504 0.85 PPARG (0.51) F9F10PPARGSLC22A12
SCHEMBL11561168 0.85 PPARG (0.51) F9F10PPARGSLC22A12
SCHEMBL11566378 0.84 F9 (0.43) F9F10L3MBTL1PPARGSLC22A12
SCHEMBL11568618 0.84 F9 (0.48) F9F10MEN1KMT2APPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4168385-A LOWERING OF STEROL AND TRIGLYCERIDE SERUM LEVELS AMERICAN CYANAMID COMPANY (US) 1979-09-18 US disclosed
US-4125729-A Hypolipemic α-aryloxy para substituted phenyl acetic acid compounds AMERICAN CYANAMID COMPANY (US) 1978-11-14 US disclosed