SCHEMBL11568618

SCHEMBL11568618

COC(=O)C(Oc1ccc2ccccc2c1)c1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F9 P00740 1/20 0.48
F10 P00742 1/20 0.48
RECQL P46063 1/20 0.43
UTS2R Q9UKP6 4/20 0.43
PTGS2 P35354 1/20 0.43
PPARG P37231 7/20 0.43
PPARD Q03181 2/20 0.43
PPARA Q07869 2/20 0.43
PARG Q86W56 1/20 0.42
SLC22A12 Q96S37 1/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
POLB P06746 1/20 0.42
CASP3 P42574 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
PLA2G7 Q13093 1/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11564504 0.88 PPARG (0.51) F9F10UTS2RPPARGPPARA
SCHEMBL11561168 0.88 PPARG (0.51) F9F10UTS2RPPARGPPARA
SCHEMBL11565422 0.88 F9 (0.46) F9F10PPARGPPARASLC22A12
SCHEMBL11566988 0.86 F9 (0.51) F9F10UTS2RPPARGPPARA
SCHEMBL11638373 0.85 F9 (0.45) F9F10UTS2RPTGS2PPARG
SCHEMBL11568593 0.84 FFAR1 (0.46) F9F10PPARGSLC22A12MEN1
SCHEMBL11566529 0.83 F9 (0.44) F9F10PPARGSLC22A12MEN1
SCHEMBL11560044 0.83 F9 (0.44) F9F10PTGS2PPARGPPARA
SCHEMBL11564359 0.83 SLC6A2 (0.49) F9F10RECQLUTS2RPTGS2
SCHEMBL11569905 0.82 F9 (0.43) F9F10PPARGSLC22A12MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4168385-A LOWERING OF STEROL AND TRIGLYCERIDE SERUM LEVELS AMERICAN CYANAMID COMPANY (US) 1979-09-18 US disclosed
US-4125729-A Hypolipemic α-aryloxy para substituted phenyl acetic acid compounds AMERICAN CYANAMID COMPANY (US) 1978-11-14 US disclosed