SCHEMBL11565422

SCHEMBL11565422

COC(=O)C(Oc1ccc(Cl)cc1)c1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
F9 P00740 1/20 0.46
F10 P00742 1/20 0.46
FNTA P49354 3/20 0.44
FNTB P49356 3/20 0.44
L3MBTL1 Q9Y468 3/20 0.43
MEN1 O00255 1/20 0.43
MAPT P10636 1/20 0.43
KMT2A Q03164 1/20 0.43
PPARG P37231 8/20 0.43
PPARA Q07869 3/20 0.43
CNR2 P34972 1/20 0.43
SLC22A12 Q96S37 1/20 0.42
CA2 P00918 1/20 0.41
MMP2 P08253 1/20 0.41
MMP9 P14780 1/20 0.41
MMP8 P22894 1/20 0.41
MMP14 P50281 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11561168 0.94 PPARG (0.51) F9F10PPARGPPARASLC22A12
SCHEMBL11564504 0.94 PPARG (0.51) F9F10PPARGPPARASLC22A12
SCHEMBL11565230 0.93 PPARG (0.45) F9F10FNTAFNTBL3MBTL1
SCHEMBL11638373 0.91 F9 (0.45) F9F10FNTAFNTBL3MBTL1
SCHEMBL11568422 0.91 POLB (0.44) F9F10FNTAFNTBMEN1
SCHEMBL11568045 0.91 PTGS2 (0.44) F9F10FNTAFNTBCNR2
SCHEMBL11567624 0.91 POLB (0.44) F9F10FNTAFNTBMEN1
SCHEMBL11568593 0.90 FFAR1 (0.46) F9F10FNTAFNTBL3MBTL1
SCHEMBL11568416 0.89 LMNA (0.45) F9F10FNTAFNTBMEN1
SCHEMBL11564430 0.89 PPARG (0.51) F9F10PPARGPPARACNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4168385-A LOWERING OF STEROL AND TRIGLYCERIDE SERUM LEVELS AMERICAN CYANAMID COMPANY (US) 1979-09-18 US disclosed
US-4125729-A Hypolipemic α-aryloxy para substituted phenyl acetic acid compounds AMERICAN CYANAMID COMPANY (US) 1978-11-14 US disclosed