Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11529928 | 0.79 | PDE4D (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11746013 | 0.79 | PDE4D (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11529917 | 0.79 | PDE4D (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11529915 | 0.79 | PDE4D (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8300622 | 0.76 | PGR (0.40) | MAOBPGRKDM4EALDH1A1HPGD | |
| SCHEMBL11531244 | 0.76 | MAOB (0.41) | MAOBPGRKDM4EALDH1A1HPGD | |
| SCHEMBL20142919 | 0.74 | PDE4B (0.35) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL11561098 | 0.74 | ALDH1A1 (0.43) | MAOBKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11396711 | 0.72 | PDE4B (0.39) | MAOBALDH1A1HPGDMAPTPDE4A | |
| SCHEMBL20142921 | 0.70 | PDE4B (0.40) | KDM4EALDH1A1SMN1; SMN2MAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3931176-A | CNS DEPRESSANT | SANDOZ INC. (US) | 1976-01-06 | — | — | US | claimed |
| US-4136184-A | TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS | SANDOZ, INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4055644-A | CNS DEPRESSANTS | SANDOZ, INC. (US) | 1977-10-25 | — | — | US | disclosed |
| US-3931176-A | CNS DEPRESSANT | SANDOZ INC. (US) | 1976-01-06 | — | — | US | disclosed |