SCHEMBL11570409

SCHEMBL11570409

O=[N+]([O-])Nc1c(Cl)cc(I)cc1I

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.33
ADRA2A P08913 1/20 0.33
CYP2D6 P10635 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
HTR1D P28221 1/20 0.33
HTR1B P28222 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
LMNA P02545 1/20 0.32
BLM P54132 1/20 0.32
ALDH1A1 P00352 2/20 0.31
TSHR P16473 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10799354 0.90 ADRA2A (0.35) CYP1A2ADRA2ACYP2D6ADRA2BADRA2C
SCHEMBL11569349 0.89
SCHEMBL10796706 0.82 NMT1 (0.35)
SCHEMBL10801949 0.79 ALDH1A1 (0.39) LMNAALDH1A1TSHR
SCHEMBL10796285 0.78 MEN1 (0.30)
SCHEMBL10796434 0.74 ALDH1A1 (0.52) ADRA2AADRA2BADRA2CLMNAALDH1A1
SCHEMBL27410297 0.72 ALDH1A1 (0.50) ADRA2AADRA2BADRA2CLMNAALDH1A1
SCHEMBL10799196 0.71 ALDH1A1 (0.33) ALDH1A1TSHR
SCHEMBL10800358 0.71 MEN1 (0.33)
SCHEMBL10801954 0.71 MEN1 (0.33) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0003880-A1 Substituted phenylnitramines with plant growth regulating properties AMERICAN CYANAMID COMPANY (US) 1979-09-05 EP claimed
EP-0003880-A1 Substituted phenylnitramines with plant growth regulating properties AMERICAN CYANAMID COMPANY (US) 1979-09-05 EP disclosed