Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.64 |
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | BAD | Q92934 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6149922 | 0.88 | RAB9A (0.52) | NPC1RAB9APTPN1CES2CES1 | |
| SCHEMBL2491432 | 0.82 | PLOD2 (0.69) | NPC1RAB9APTPN1CES2CES1 | |
| SCHEMBL26584242 | 0.82 | NPC1 (0.82) | NPC1RAB9APTPN1CES2CES1 | |
| SCHEMBL633279 | 0.81 | NPC1 (0.72) | NPC1RAB9APTPN1CES2CES1 | |
| SCHEMBL9909660 | 0.80 | PTPN1 (0.41) | NPC1RAB9APTPN1CES1HTR7 | |
| SCHEMBL1094528 | 0.80 | NPC1 (0.64) | NPC1RAB9APTPN1CES2CES1 | |
| SCHEMBL310879 | 0.80 | NPC1 (0.60) | NPC1RAB9APTPN1CA1CA2 | |
| SCHEMBL1266504 | 0.80 | NPC1 (0.64) | NPC1RAB9APTPN1CES2CES1 | |
| SCHEMBL1146715 | 0.80 | TSHR (0.60) | CES2CES1CA1CA2SMN1; SMN2 | |
| SCHEMBL2074862 | 0.79 | PLOD2 (0.60) | NPC1RAB9APTPN1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114671737-B | Preparation method of posaconazole main ring intermediate | 张家口市格瑞高新技术有限公司 | 2023-10-24 | — | — | CN | claimed |
| CN-115073276-A | Preparation and control method of posaconazole main ring impurity | 济南大学 | 2022-09-20 | — | — | CN | claimed |
| CN-114671737-A | Preparation method of posaconazole main ring intermediate | 张家口市格瑞高新技术有限公司 | 2022-06-28 | — | — | CN | claimed |
| CN-111606848-A | Preparation method of fluorodiphenyl substituted pyridine compound | 广西民族大学 | 2020-09-01 | — | — | CN | claimed |
| CN-102531870-A | Preparation method of 2,4-difluoroacetophenone | SHANGHAI SINOFLUORO SCIENT CO | 2012-07-04 | — | — | CN | claimed |
| EP-0694519-B1 | Process for the preparation of 2,4-difluoroacetophenone | CLARIANT GMBH (DE) | 1999-06-16 | — | — | EP | claimed |
| EP-0694519-A1 | Process for the preparation of 2,4-difluoroacetophenone | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-01-31 | — | — | EP | claimed |
| JP-8099926-A | — | — | None | — | — | JP | disclosed |
| US-12258330-B2 | Method for preparing voriconazole and intermediate thereof | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2025-03-25 | — | — | US | disclosed |
| CN-118047736-A | Synthesis method of 2,2', 6' -tetrafluoro- [1,1' -biphenyl ] compounds | 广州佳途科技股份有限公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-117417334-A | Azole derivative containing isoxazole structure, and preparation method and application thereof | 沈阳药科大学 | 2024-01-19 | — | — | CN | disclosed |
| CN-114989141-B | Lenalidomide derivative and preparation method and application thereof | 济南爱思医药科技有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-117143016-A | Synthesis process of 1-cyclopropyl-7-fluoro-8-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid | 奥盖尼克材料(苏州)有限公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-1992016515-A1 | FUNGICIDAL 4-THIOXOOXAZOLIDIN-2-ONES AND 4-IMINOOXAZOLINDIN-2-ONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0503798-A1 | Fungicidal 4-thixooxazolidin-2-ones and 4-iminooxazolindin-2-ones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-09-16 | — | — | EP | disclosed |
| EP-0472392-A2 | Optically active triazole derivatives and compositions | ZENECA LIMITED (GB) | 1992-02-26 | — | — | EP | disclosed |
| WO-1992002509-A1 | HERBICIDAL SUBSTITUTED ARYL ALKYLSULFONYL PYRAZOLES | MONSANTO COMPANY (US) | 1992-02-20 | — | — | WO | disclosed |
| EP-0443513-A2 | Azoxy compounds | KOWA COMPANY, LTD. (JP) | 1991-08-28 | — | — | EP | disclosed |
| EP-0165775-A1 | Antifungal azole compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-12-27 | — | — | EP | disclosed |
| US-4215044-A | FLUORINATION OF AN UNSATURATED SILANOL COMPOUND WITH A PERHALOGENATED HYPOFLUORITE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12258330-B2 | Method for preparing voriconazole and intermediate thereof | CYP51A1, PANK3, CYP3A4 | NPC1 989/4885RAB9A 4052/4885PTPN1 4619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.