SCHEMBL11575211

SCHEMBL11575211

Cc1ccc(Sc2ccc(C)cc2CC#N)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 8/20 0.42
HTR3A P46098 8/20 0.42
MAPT P10636 6/20 0.38
ALDH1A1 P00352 4/20 0.38
MCL1 Q07820 2/20 0.37
HPGD P15428 3/20 0.37
PKM P14618 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
L3MBTL1 Q9Y468 3/20 0.36
ALOX15 P16050 2/20 0.36
MAPK1 P28482 2/20 0.36
HSD17B10 Q99714 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
GAA P10253 1/20 0.36
KDM4E B2RXH2 2/20 0.35
LMNA P02545 1/20 0.35
CYP1A2 P05177 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11758024 0.92 SLC6A4 (0.41) HTR1AHTR3AMAPTALDH1A1MCL1
SCHEMBL11615331 0.91 HTR1A (0.48) HTR1AHTR3AMAPTALDH1A1HPGD
SCHEMBL11760701 0.91 HTR1A (0.47) HTR1AHTR3AMAPTALDH1A1HPGD
SCHEMBL11709008 0.90 HTR1A (0.45) HTR1AHTR3AMAPTALDH1A1HPGD
SCHEMBL11759685 0.81 SLC6A4 (0.39) HTR1AHTR3AMAPTALDH1A1MCL1
SCHEMBL11760425 0.78 HTR1A (0.42) HTR1AHTR3AMAPTALDH1A1HPGD
SCHEMBL11578003 0.77 MAPT (0.50) HTR1AHTR3AMAPTALDH1A1HPGD
SCHEMBL11576431 0.77 HPGD (0.46) HTR1AHTR3AMAPTALDH1A1HPGD
SCHEMBL11759395 0.75 CYP2A6 (0.42) MAPTALDH1A1HPGDSLC6A2SLC6A4
SCHEMBL11757804 0.75 AGBL2 (0.44) HTR1AHTR3AMAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4118572-A CNS DEPRESSANTS, NEUROLEPTIC AGENTS, SCHIZOPHRENIA, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-10-03 US disclosed
US-4105664-A Dibenz[b,f]oxepin derivatives HOFFMANN-LA ROCHE INC. (US) 1978-08-08 US disclosed
US-4100173-A DEPRESSANTS, SCHIZOPHRENIA, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-07-11 US disclosed
US-4091023-A ANTISCHIZOPHRENIA AGENTS, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-05-23 US disclosed
US-4032525-A CNS DEPRESSANTS, NEUROLEPTICS HOFFMANN-LA ROCHE INC. (US) 1977-06-28 US disclosed