Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 7/20 | 0.37 |
| ▸ | HTR3A | P46098 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11575211 | 0.92 | HTR1A (0.42) | SLC6A4SLC6A2SLC6A3HTR1AHTR3A | |
| SCHEMBL11759685 | 0.89 | SLC6A4 (0.39) | SLC6A4SLC6A2SLC6A3HTR1AHTR3A | |
| SCHEMBL11615331 | 0.87 | HTR1A (0.48) | SLC6A4SLC6A2SLC6A3HTR1AHTR3A | |
| SCHEMBL11760701 | 0.87 | HTR1A (0.47) | SLC6A4HTR1AHTR3AMAPTALDH1A1 | |
| SCHEMBL11709008 | 0.86 | HTR1A (0.45) | SLC6A4SLC6A2SLC6A3HTR1AHTR3A | |
| SCHEMBL11757804 | 0.84 | AGBL2 (0.44) | SLC6A4SLC6A2SLC6A3HTR1AHTR3A | |
| SCHEMBL11759395 | 0.84 | CYP2A6 (0.42) | SLC6A4SLC6A2SLC6A3MAPTALDH1A1 | |
| SCHEMBL11875217 | 0.81 | SLC6A4 (0.46) | SLC6A4SLC6A2SLC6A3HTR1AHTR3A | |
| SCHEMBL11759425 | 0.80 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3HTR1AHTR3A | |
| SCHEMBL11763884 | 0.80 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3HTR1AHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4044010-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3954764-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1976-05-04 | — | — | US | disclosed |
| US-3954769-A | NEUROLEPTIC AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1976-05-04 | — | — | US | disclosed |