Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.52 |
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.52 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244640 | 0.93 | ADRB2 (0.60) | KMT2ALMNAMAPK1HTR7ADRB2 | |
| SCHEMBL11244639 | 0.93 | ADRB2 (0.60) | KMT2ALMNAMAPK1HTR7ADRB2 | |
| SCHEMBL11573996 | 0.93 | ADRB2 (0.60) | KMT2ALMNAMAPK1HTR7ADRB2 | |
| SCHEMBL11456005 | 0.93 | ADRB2 (0.60) | KMT2ALMNAMAPK1HTR7ADRB2 | |
| Maleic Acid SCHEMBL11577316 | 0.88 | CYP2D6 (0.53) | KMT2ALMNAMAPK1THRBHTR7 | |
| SCHEMBL11456002 | 0.86 | ADRB2 (0.56) | KMT2ALMNAMAPK1THRBHTR7 | |
| SCHEMBL11456001 | 0.86 | ADRB2 (0.56) | KMT2ALMNAMAPK1THRBHTR7 | |
| SCHEMBL11246083 | 0.86 | ADRB2 (0.56) | KMT2ALMNAMAPK1THRBHTR7 | |
| SCHEMBL11246088 | 0.86 | ADRB2 (0.56) | KMT2ALMNAMAPK1THRBHTR7 | |
| Hydrochloric Acid SCHEMBL11253835 | 0.85 | MAPT (0.56) | KMT2ALMNAMAPK1THRBHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005142-A1 | Phenylpiperazine derivatives, process for their preparation, intermediates for this purpose and medicaments containing such phenylpiperazine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-11-14 | — | — | EP | disclosed |