Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 4/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 4/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.37 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11574865 | 0.98 | APOBEC3A (0.40) | CHRNA7APOBEC3AAPOBEC3GPABPC1EIF4H | |
| SCHEMBL5298667 | 0.98 | CHRNA7 (0.38) | CHRNA7APOBEC3AAPOBEC3GPABPC1EIF4H | |
| SCHEMBL5944519 | 0.96 | CHRNA7 (0.37) | CHRNA7APOBEC3AAPOBEC3GPABPC1EIF4H | |
| SCHEMBL813764 | 0.89 | CHRNA7 (0.41) | CHRNA7APOBEC3AAPOBEC3GKMT2ACYP1A2 | |
| SCHEMBL5285109 | 0.81 | NPC1 (0.40) | CHRNA7APOBEC3AAPOBEC3GPABPC1EIF4H | |
| SCHEMBL5944444 | 0.79 | NPC1 (0.42) | CHRNA7APOBEC3AAPOBEC3GPABPC1EIF4H | |
| SCHEMBL15293602 | 0.79 | CYP1A2 (0.56) | CHRNA7APOBEC3AAPOBEC3GKMT2ACYP1A2 | |
| SCHEMBL9538584 | 0.79 | CHRNA7 (0.35) | CHRNA7KMT2ACYP1A2CYP2C9LMNA | |
| SCHEMBL5944547 | 0.78 | LMNA (0.37) | KMT2AALDH1A1LMNAHTTMEN1 | |
| SCHEMBL5298531 | 0.78 | APOBEC3A (0.37) | APOBEC3AAPOBEC3GPABPC1EIF4HKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4124630-A | Process for the production of chloromethyl thiocyanate | OFFERMANNS HERIBERT | 1978-11-07 | — | — | US | disclosed |