SCHEMBL11577397

SCHEMBL11577397

CC(C)c1cc(Cl)c(OO)c(C(C)C)c1OO

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.40
GABRA1 P14867 1/20 0.36
GABRB1 P18505 1/20 0.36
THRB P10828 6/20 0.34
THRA P10827 5/20 0.34
RORC P51449 1/20 0.33
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3271576 0.86 CA1 (0.36) LMNAGABRA1GABRB1CA1CA2
SCHEMBL11574289 0.78 LMNA (0.33) LMNATHRBTHRACA1CA2
SCHEMBL3271549 0.71
SCHEMBL11574434 0.70 PDK1 (0.39) LMNA
SCHEMBL27520749 0.69 LMNA (0.36) LMNAGABRA1GABRB1THRBTHRA
SCHEMBL3267228 0.69 GABRA1 (0.50) GABRA1GABRB1CA1CA2
SCHEMBL5587398 0.68 GABRA1 (0.40) LMNAGABRA1GABRB1THRBTHRA
SCHEMBL18348921 0.68 LMNA (0.45) LMNAGABRA1GABRB1CA1CA2
SCHEMBL5589297 0.67 GABRA1 (0.58) LMNAGABRA1GABRB1CA1CA2
SCHEMBL1877670 0.67 CA1 (0.34) LMNAGABRA1GABRB1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4088699-A PRODUCTION OF ARALKYL TERTIARY HYDROPEROXIDES THE GOODYEAR TIRE & RUBBER COMPANY (US) 1978-05-09 US disclosed
US-4080386-A OXIDATION OF AN ARYL TERTIARY ALKANE, TREATING RECYCLE STREAM WITH AN ALKALINE EXTRACTANT THE GOODYEAR TIRE & RUBBER CO. (US) 1978-03-21 US disclosed
US-3978142-A BY ACID REARRANGEMENT 3978142 MOD 3978142 AND CLEAVAGE OF ARALKYL TERTIARY POLYHYDROPEROXIDE THE GOODYEAR TIRE & RUBBER COMPANY (US) 1976-08-31 US disclosed