Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.65 |
| ▸ | CA1 | P00915 | 17/20 | 0.65 |
| ▸ | CA4 | P22748 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL320062 | 0.97 | CA2 (0.68) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL11577501 | 0.93 | CA2 (0.65) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL28535771 | 0.93 | CA2 (0.65) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL26133489 | 0.93 | CA2 (0.65) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL9130683 | 0.93 | CA2 (0.65) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL2841686 | 0.90 | CA2 (0.78) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL6665082 | 0.90 | CA2 (0.68) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL21958268 | 0.90 | CA2 (0.68) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL20704875 | 0.90 | CA2 (0.68) | CA2CA1CA4TP53TSHR | |
| Terephthalic Acid SCHEMBL10900872 | 0.90 | CA2 (0.68) | CA2CA1CA4TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4101523-A | POLYETHYLENE TEREPHTHALATE, CALCIUM TEREPHTHALATE ANHYDRIDE PARTICLES | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1978-07-18 | — | — | US | disclosed |
| US-4096109-A | POLYETHYLENE TEREPHTHALATE, INERT PARTICLES | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1978-06-20 | — | — | US | disclosed |