Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11577453 | 0.88 | GAA (0.71) | GAANPSR1LMNAHTTSMN1; SMN2 | |
| SCHEMBL11579754 | 0.85 | PTPN11 (0.58) | GAAPTPN11PTPN1PTPN6PPARG | |
| SCHEMBL11576174 | 0.80 | GAA (1.00) | GAANPSR1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5093658 | 0.80 | PTPN11 (0.66) | PTPN11PTPN1PTPN6THRATHRB | |
| SCHEMBL5138907 | 0.80 | PTPN11 (0.66) | PTPN11PTPN1PTPN6THRATHRB | |
| SCHEMBL14823517 | 0.79 | GAA (0.59) | GAANPSR1PTPN11PTPN1PTPN6 | |
| SCHEMBL12327982 | 0.79 | CA5A (0.59) | GAANPSR1PTPN11PTPN1PTPN6 | |
| SCHEMBL28669480 | 0.78 | ALDH1A1 (0.53) | GAANPSR1PTPN11PTPN1PTPN6 | |
| SCHEMBL30159686 | 0.78 | ALDH1A1 (0.53) | GAANPSR1PTPN11PTPN1PTPN6 | |
| SCHEMBL11577926 | 0.77 | GAA (0.70) | GAANPSR1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4075344-A | 3-ALKOXYISOQUINOLINES FOR HYPOTENSIVE AND VASODILATING EFFECTS | MEAD JOHNSON & COMPANY (US) | 1978-02-21 | — | — | US | disclosed |
| US-4015006-A | 3(2H)-Isoquinolones therapeutic process | MEAD JOHNSON & COMPANY (US) | 1977-03-29 | — | — | US | disclosed |