SCHEMBL11580338

SCHEMBL11580338

O=C(/C=C\c1ccccc1)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1B1 Q16678 10/20 0.68
MAOB P27338 6/20 0.62
MAPT P10636 5/20 0.62
TNFRSF1A P19438 3/20 0.62
PLIN1 O60240 1/20 0.62
LMNA P02545 1/20 0.62
BCHE P06276 1/20 0.62
ACHE P22303 1/20 0.62
RECQL P46063 1/20 0.62
PLIN5 Q00G26 1/20 0.62
ABHD5 Q8WTS1 1/20 0.62
KMT2A Q03164 3/20 0.60
MEN1 O00255 2/20 0.60
HSPD1 P10809 2/20 0.60
HSPE1 P61604 2/20 0.60
ALDH2 P05091 1/20 0.60
CYP3A4 P08684 1/20 0.60
CYP19A1 P11511 1/20 0.60
F3 P13726 1/20 0.60
MAOA P21397 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11578509 1.00 CYP1B1 (0.68) CYP1B1MAOBMAPTTNFRSF1APLIN1
SCHEMBL30504727 0.86 PTGS2 (0.62) CYP1B1MAOBCYP3A4MAOAALOX5
SCHEMBL7312933 0.85 F3 (0.69) CYP1B1MAOBMAPTRECQLKMT2A
SCHEMBL7306057 0.85 F3 (0.69) CYP1B1MAOBMAPTRECQLKMT2A
SCHEMBL9337927 0.84 MAPT (0.70) CYP1B1MAOBMAPTLMNAKMT2A
SCHEMBL656338 0.83 CYP1B1 (0.69) CYP1B1MAOBMAPTTNFRSF1APLIN1
SCHEMBL656339 0.83 CYP1B1 (0.69) CYP1B1MAOBMAPTTNFRSF1APLIN1
SCHEMBL13698858 0.81 P4HB (0.61) CYP1B1MAOBCYP3A4F3MAOA
SCHEMBL196424 0.81 CYP1B1 (1.00) CYP1B1MAOBMAPTTNFRSF1APLIN1
SCHEMBL10415521 0.81 CYP1B1 (1.00) CYP1B1MAOBMAPTTNFRSF1APLIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4113465-A 3-(1,2,4-TRIAZOLYL)-3-PHENYLPROPIOPHENONES IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1978-09-12 US disclosed