Bithionol

Bithionol

SCHEMBL1158099

Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O.[NaH].[NaH]

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 8/20 0.95
ALDH1A1 P00352 5/20 0.95
HPGD P15428 5/20 0.95
TSHR P16473 5/20 0.95
CYP3A4 P08684 4/20 0.95
MEN1 O00255 4/20 0.95
KMT2A Q03164 4/20 0.95
ALOX15 P16050 4/20 0.95
RECQL P46063 3/20 0.95
MAPK1 P28482 3/20 0.95
ALOX12 P18054 3/20 0.95
SMN1; SMN2 Q16637 3/20 0.95
HIF1A Q16665 3/20 0.95
KDM4E B2RXH2 2/20 0.95
MAPT P10636 2/20 0.95
CASP1 P29466 2/20 0.95
CASP7 P55210 2/20 0.95
HTT P42858 2/20 0.95
TTR P02766 2/20 0.95
THRB P10828 2/20 0.95

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bithionol SCHEMBL23926397 1.00 HSD17B10 (0.95) HSD17B10ALDH1A1HPGDTSHRCYP3A4
Bithionol SCHEMBL29352300 0.98 HSD17B10 (1.00) HSD17B10ALDH1A1HPGDTSHRCYP3A4
Bithionol SCHEMBL64385 0.98 HSD17B10 (1.00) HSD17B10ALDH1A1HPGDTSHRCYP3A4
Bithionol SCHEMBL10392807 0.95 HSD17B10 (0.95) HSD17B10ALDH1A1HPGDTSHRCYP3A4
Bithionol SCHEMBL29988662 0.95 HSD17B10 (0.95) HSD17B10ALDH1A1HPGDTSHRCYP3A4
SCHEMBL12655293 0.89 HSD17B10 (0.83) HSD17B10ALDH1A1HPGDTSHRCYP3A4
SCHEMBL14644985 0.86 HSD17B10 (0.77) HSD17B10ALDH1A1HPGDTSHRCYP3A4
SCHEMBL19197511 0.86 MEN1 (0.77) HSD17B10ALDH1A1HPGDTSHRCYP3A4
SCHEMBL9328645 0.84 HSD17B10 (0.74) HSD17B10ALDH1A1HPGDTSHRCYP3A4
Bithionol SCHEMBL636174 0.84 HSD17B10 (0.78) HSD17B10ALDH1A1HPGDTSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080261722-A1 COMPOSITIONS FOR USE IN GOLF BALLS ACUSHNET COMPANY 2008-10-23 US claimed
US-7888417-B2 core or the layer includes a composition formed from a base polymer, a crosslink initiator, and at least one additive; additive has at least one carbon-oxygen-boron linkage, carbon in the linkage being a secondary or tertiary carbon; enhances coefficient of restitution and/or reduces compression of core ACUSHNET COMPANY (US) 2011-02-15 US disclosed
US-20080261722-A1 COMPOSITIONS FOR USE IN GOLF BALLS ACUSHNET COMPANY 2008-10-23 US disclosed
US-20080227567-A1 COMPOSITIONS FOR USE IN GOLF BALLS ACUSHNET COMPANY 2008-09-18 US disclosed
US-20080176678-A1 Compositions for Use in Golf Balls ACUSHNET COMPANY 2008-07-24 US disclosed
US-7361711-B2 Compositions for use in golf balls ACUSHNET COMPANY (US) 2008-04-22 US disclosed
US-7358310-B2 Compositions for use in golf balls ACUSHNET COMPANY (US) 2008-04-15 US disclosed
US-7358309-B2 core or the layer includes a composition formed from a base polymer, a crosslink initiator, and at least one additive; additive has at least one carbon-oxygen-boron linkage, carbon in the linkage being a secondary or tertiary carbon; enhances coefficient of restitution and/or reduces compression of core ACUSHNET COMPANY (US) 2008-04-15 US disclosed
US-7358308-B2 Compositions for use in golf balls ACUSHNET COMPANY (US) 2008-04-15 US disclosed
US-20060281586-A1 Compositions for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2006-12-14 US disclosed
US-20060281587-A1 Compositions for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2006-12-14 US disclosed
US-20050245657-A1 Compositions for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2005-11-03 US disclosed
US-20050245652-A1 Compositions for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2005-11-03 US disclosed
US-4482759-A Fungicidally active benzhydrol derivatives DEGUSSA AKTIENGESELLSCHAFT (DE) 1984-11-13 US disclosed
US-3932509-A FUNGICIDES, VIRICIDES CIBA-GEIGY CORPORATION (US) 1976-01-13 US disclosed