Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 7/20 | 0.50 |
| ▸ | PPARD | Q03181 | 7/20 | 0.50 |
| ▸ | PPARA | Q07869 | 7/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11357288 | 1.00 | NAAA (0.54) | NAAACES2GPR84PPARGPPARD | |
| Bicarbonate SCHEMBL7176348 | 1.00 | NAAA (0.54) | NAAACES2GPR84PPARGPPARD | |
| Bicarbonate SCHEMBL10454811 | 1.00 | NAAA (0.54) | NAAACES2GPR84PPARGPPARD | |
| Bicarbonate SCHEMBL302223 | 1.00 | NAAA (0.54) | NAAACES2GPR84PPARGPPARD | |
| Bicarbonate SCHEMBL6445984 | 1.00 | NAAA (0.54) | NAAACES2GPR84PPARGPPARD | |
| Bicarbonate SCHEMBL27832806 | 0.93 | NAAA (0.48) | NAAACES2GPR84PPARGPPARD | |
| Bicarbonate SCHEMBL1538407 | 0.89 | ALDH1A1 (0.52) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL11357290 | 0.88 | NAAA (0.54) | NAAACES2GPR84PPARGPPARD | |
| SCHEMBL30203815 | 0.88 | NAAA (0.54) | NAAACES2GPR84PPARGPPARD | |
| SCHEMBL302224 | 0.88 | NAAA (0.54) | NAAACES2GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4121885-A | Method to produce a composite contact lens | PRECISION COSMET CO., INC. (US) | 1978-10-24 | — | — | US | disclosed |
| US-4093361-A | Composite prosthetic polymeric devices | PRECISION COSMET CO., INC. (US) | 1978-06-06 | — | — | US | disclosed |