Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | APOB | P04114 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11586182 | 0.89 | EGFR (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11585659 | 0.87 | KMT2A (0.41) | SMN1; SMN2KMT2AALDH1A1PDK2 | |
| SCHEMBL11587639 | 0.84 | HPGD (0.35) | SMN1; SMN2MEN1KMT2AHSD17B10RAB9A | |
| SCHEMBL11588154 | 0.84 | APOB (0.37) | SMN1; SMN2MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL11587446 | 0.83 | PDK2 (0.40) | MEN1KMT2ARAB9AMAPTKDM4E | |
| SCHEMBL11586971 | 0.81 | HTR2A (0.42) | PDK2 | |
| SCHEMBL11586311 | 0.80 | MC4R (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11632020 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL11587730 | 0.78 | ALDH1A1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11585500 | 0.78 | EGFR (0.40) | MEN1KMT2AMAPTPTGDRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4070387-A | ANTIARRHYTHMIC AGENTS | MERCK & CO., INC. (US) | 1978-01-24 | — | — | US | disclosed |
| US-4020096-A | ANTIARRYTHMIA | MERCK & CO., INC. (US) | 1977-04-26 | — | — | US | disclosed |
| US-3950423-A | 10,11-Dihydro-10,10,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene-5-methylamines | MERCK & CO., INC. (US) | 1976-04-13 | — | — | US | disclosed |