Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propiophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyrophenone SCHEMBL11798375 | 0.86 | L3MBTL1 (0.59) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 | |
| Propiophenone SCHEMBL14244535 | 0.84 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 | |
| Propiophenone SCHEMBL318818 | 0.84 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 | |
| Propiophenone SCHEMBL76464 | 0.84 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 | |
| Valerophenone SCHEMBL11586217 | 0.83 | L3MBTL1 (0.55) | MAPTSMN1; SMN2L3MBTL1HPGDCES1 | |
| Propiophenone SCHEMBL27783343 | 0.82 | MAPT (0.62) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 | |
| Dipentylamine SCHEMBL28010569 | 0.82 | NAAA (0.58) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 | |
| Propiophenone SCHEMBL9364510 | 0.82 | MAPT (0.67) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 | |
| Propiophenone SCHEMBL8603451 | 0.82 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 | |
| Propiophenone SCHEMBL3647864 | 0.82 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2L3MBTL1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE29653-E | PARA-DI-(HYDROXYALKYL)AMINO BENZOIC ACID ESTERS | WESTWOOD PHARMACEUTICALS, INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-3953589-A | HYDROXYALKYL-AMINO-ACYL PHENONES | WESTWOOD PHARMACEUTICALS, INC. (US) | 1976-04-27 | — | — | US | disclosed |