Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Butyrophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valerophenone SCHEMBL11586217 | 0.90 | L3MBTL1 (0.55) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 | |
| Propiophenone SCHEMBL11587987 | 0.86 | MAPT (0.56) | L3MBTL1HPGDSMN1; SMN2CES1CES2 | |
| Butyrophenone SCHEMBL82532 | 0.85 | L3MBTL1 (0.77) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 | |
| Butyrophenone SCHEMBL11522791 | 0.85 | L3MBTL1 (0.77) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 | |
| Butyrophenone SCHEMBL9725428 | 0.85 | L3MBTL1 (0.77) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 | |
| Butyrophenone SCHEMBL25423577 | 0.85 | L3MBTL1 (0.77) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 | |
| Butyrophenone SCHEMBL27921458 | 0.83 | L3MBTL1 (0.74) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 | |
| Butyrophenone SCHEMBL28260771 | 0.83 | L3MBTL1 (0.74) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 | |
| Butyrophenone SCHEMBL11310788 | 0.83 | L3MBTL1 (0.74) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 | |
| Butyrophenone SCHEMBL7218951 | 0.83 | L3MBTL1 (0.74) | L3MBTL1HPGDSMN1; SMN2HSD17B3CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3953589-A | HYDROXYALKYL-AMINO-ACYL PHENONES | WESTWOOD PHARMACEUTICALS, INC. (US) | 1976-04-27 | — | — | US | disclosed |