Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | CASP1 | P29466 | 4/20 | 0.52 |
| ▸ | CASP7 | P55210 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TYMS | P04818 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11696687 | 0.88 | KDM4E (0.56) | CDK5CDK5R1KDM4EALDH1A1HPGD | |
| SCHEMBL11331679 | 0.80 | CDK5 (0.63) | CDK5CDK5R1MAPTTP53SMN1; SMN2 | |
| SCHEMBL11333142 | 0.77 | CDK5 (0.59) | CDK5CDK5R1KDM4EALDH1A1HPGD | |
| SCHEMBL11651866 | 0.77 | CDK5 (0.59) | CDK5CDK5R1MAPTTP53SMN1; SMN2 | |
| SCHEMBL11832606 | 0.76 | ALDH1A1 (0.41) | CDK5CDK5R1MAPTTP53SMN1; SMN2 | |
| SCHEMBL14919686 | 0.76 | RORC (0.77) | CDK5CDK5R1MAPTTP53SMN1; SMN2 | |
| SCHEMBL9450612 | 0.75 | CDK5 (0.72) | CDK5CDK5R1MAPTTP53SMN1; SMN2 | |
| SCHEMBL25837913 | 0.74 | KDR (0.55) | CDK5CDK5R1MAPTTP53SMN1; SMN2 | |
| SCHEMBL1097083 | 0.73 | CDK5 (0.66) | CDK5CDK5R1MAPTTP53SMN1; SMN2 | |
| SCHEMBL9450624 | 0.73 | KDM4E (0.73) | CDK5CDK5R1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE29834-E | PREPARED FROM 4-SULFONYL-1,8-NAPHTHOLACTAMS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-11-14 | — | — | US | disclosed |
| US-3959310-A | BENZINDOLE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-25 | — | — | US | disclosed |