SCHEMBL29369705

SCHEMBL29369705

O=C1NCCc2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 12/20 1.00
PARP1 P09874 10/20 1.00
PARP11 Q9NR21 8/20 1.00
PDPK1 O15530 1/20 1.00
CA12 O43570 1/20 0.63
CA9 Q16790 1/20 0.63
TUBB4A P04350 1/20 0.58
TUBB P07437 1/20 0.58
TUBA3C P0DPH7 1/20 0.58
TUBA1B P68363 1/20 0.58
TUBA4A P68366 1/20 0.58
TUBB4B P68371 1/20 0.58
TUBB3 Q13509 1/20 0.58
TUBB2A Q13885 1/20 0.58
TUBB8 Q3ZCM7 1/20 0.58
TUBA3E Q6PEY2 1/20 0.58
TUBA1A Q71U36 1/20 0.58
TUBA1C Q9BQE3 1/20 0.58
TUBB6 Q9BUF5 1/20 0.58
TUBB2B Q9BVA1 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL67710 1.00 PARP10 (1.00) PARP10PARP1PARP11PDPK1CA12
Hydrochloric Acid SCHEMBL29896921 0.98 PARP10 (0.96) PARP10PARP1PARP11PDPK1CA12
Hydrochloric Acid SCHEMBL10647408 0.98 PARP10 (0.96) PARP10PARP1PARP11PDPK1CA12
Piperazine SCHEMBL28321362 0.94 PARP10 (0.89) PARP10PARP1PARP11PDPK1CA12
SCHEMBL1894080 0.88 PARP10 (0.78) PARP10PARP1PARP11PDPK1CA12
SCHEMBL20076060 0.86 PARP10 (0.75) PARP10PARP1PARP11PDPK1CA12
SCHEMBL29752161 0.86 PARP10 (0.75) PARP10PARP1PARP11PDPK1CA12
Trifluoroacetic Acid SCHEMBL28415123 0.85 PARP10 (0.72) PARP10PARP1PARP11PDPK1CA12
SCHEMBL28691391 0.82 PARP1 (0.68) PARP10PARP1PARP11PDPK1CA12
SCHEMBL30114663 0.81 PARP10 (0.67) PARP10PARP1PARP11PDPK1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 205 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3768675-B1 NOVEL TRIAZOLONE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME YUHAN CORP (KR) 2026-04-01 EP claimed
US-20250178999-A1 ONE STEP SYNTHESIS OF 1-TETRALONE COMPOUNDS AND USES THEREOF IN THE PREPARATION OF (+)-TETRALONE ABSCISIC ACID (ABA) UNIVERSITY OF SASKATCHEWAN (CA) 2025-06-05 US claimed
CN-119823040-A Preparation method of amido-containing 3, 4-dihydro-isoquinoline-1 (2H) -ketone derivative 浙江理工大学嵊州创新研究院有限公司 2025-04-15 CN claimed
EP-4514784-A1 ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE Petra Pharma Corporation (US) 2025-03-05 EP claimed
CN-119506909-A Method for electrochemically synthesizing 3, 4-dihydro-isoquinoline-1 (2H) -ketone compound 宜宾学院 2025-02-25 CN claimed
CN-119301106-A Allosteric benzopyrone inhibitors of phosphoinositide 3-kinase (PI 3K) for the treatment of disease 佩特拉制药公司 2025-01-10 CN claimed
EP-4050006-B1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO LTD (KR) 2025-01-01 EP claimed
CN-118894816-A 3, 3-Difluoroallylamine or salt thereof and pharmaceutical composition comprising the same 柳韩洋行 2024-11-05 CN claimed
CN-118791431-A Dihydro-isoquinolone compounds and isoindoles Selective synthesis method of pinone compound 常州大学 2024-10-18 CN claimed
EP-4415818-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS BioSplice Therapeutics, Inc. (US) 2024-08-21 EP claimed
CN-113330001-B 3, 3-Difluoroallylamine or salt thereof and pharmaceutical composition comprising the same 柳韩洋行 2024-07-02 CN claimed
EP-3386511-B2 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2024-03-20 EP claimed
CN-115515947-B SHP2 inhibitor, composition and application thereof 贝达药业股份有限公司 2024-02-06 CN claimed
CN-111886233-B Triazolone derivatives or salts thereof and pharmaceutical compositions containing the same 柳韩洋行 2024-01-02 CN claimed
WO-2023212693-A1 ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE PETRA PHARMA CORPORATION (US) 2023-11-02 WO claimed
WO-2023064361-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS BIOSPLICE THERAPEUTICS, INC. (US) 2023-04-20 WO claimed
CN-111825656-B Inhibitors of protein arginine methyltransferase 5 (PRMT 5), pharmaceutical products thereof, and methods thereof 南京药石科技股份有限公司 2023-03-31 CN claimed
CN-115515947-A SHP2 inhibitor and composition and application thereof 贝达药业股份有限公司 2022-12-23 CN claimed
CN-115093369-A Synthetic method of 3, 4-dihydroisoquinoline-1-ketone compound 浙大城市学院 2022-09-23 CN claimed
EP-4747250-A1 KINASE INHIBITORS The United States Of America, As Represented By The Secretary, Department of Health and Human Services (US) 2026-05-27 EP disclosed
CN-122094935-A Amide prodrugs and uses thereof 2026-05-26 CN disclosed
US-12637461-B2 Compounds for the activation of AMPK PFIZER INC. (US) 2026-05-26 US disclosed
CN-115835909-B Cannabinoid receptor type 2 (CB 2) modulators and uses thereof 泰昂治疗公司 2026-05-15 CN disclosed
US-20260132132-A1 3A,4,5,6-TETRAHYDRO-1 H-PYRAZOLO[3,4-C]PYRIDIN-7(7AH)-ONE DERIVATIVES AS FACTOR XIIA INHIBITORS KALVISTA PHARMACEUTICALS LTD (GB) 2026-05-14 US disclosed
CN-116583303-B Tripterine conjugates and uses thereof 瑞阳公司 2026-05-12 CN disclosed
EP-4694931-A1 EXTRAHEPATIC DELIVERY OF DOUBLE-STRANDED RNA AGENTS Alnylam Pharmaceuticals, Inc. (US) 2026-02-18 EP disclosed
EP-4448513-A4 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF BEIGENE SWITZERLAND GMBH (CH) 2025-11-05 EP disclosed
US-20250320184-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2025-10-16 US disclosed
US-12391674-B2 Heterocyclic compounds for the treatment of epilepsy OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-08-19 US disclosed
US-12331035-B2 Bicyclic compound and use thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2025-06-17 US disclosed
CN-120152713-A Tricyclic aryl derivatives and compositions and methods thereof 昂胜医疗科技公司 2025-06-13 CN disclosed
US-20250178999-A1 ONE STEP SYNTHESIS OF 1-TETRALONE COMPOUNDS AND USES THEREOF IN THE PREPARATION OF (+)-TETRALONE ABSCISIC ACID (ABA) UNIVERSITY OF SASKATCHEWAN (CA) 2025-06-05 US disclosed
CN-120051461-A VHH antibody conjugates 雅博得乐医疗公司 2025-05-27 CN disclosed
CN-120025312-A Benzazepine derivatives 大塚制药株式会社 2025-05-23 CN disclosed
CN-114516856-B Dihydro-isoquinolinone and isoindolinone derivatives and application thereof 安徽中科拓苒药物科学研究有限公司 2025-05-23 CN disclosed
CN-114516856-B Dihydro-isoquinolinone and isoindolinone derivatives and application thereof 安徽中科拓苒药物科学研究有限公司 2025-05-23 CN disclosed
US-20250161247-A1 METHOD FOR TREATING BREAST CANCERS AND PARP RESISTANT BREAST CANCERS LANTERN PHARMA INC. (US) 2025-05-22 US disclosed
EP-4554683-A2 METHOD FOR TREATING BREAST CANCERS AND PARP RESISTANT BREAST CANCERS Lantern Pharma Inc. (US) 2025-05-21 EP disclosed
CN-119930578-A Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith 细胞基因公司 2025-05-06 CN disclosed
CN-119907795-A Antibacterial compounds 布莱克史密斯医药公司 2025-04-29 CN disclosed
EP-4536350-A1 SUBSTITUTED 3,4-DIHYDROISOQUINOLIN-1(2H)-ONE DERIVATIVES AND RELATED USES Nodthera Limited (GB) 2025-04-16 EP disclosed
EP-4536640-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2025-04-16 EP disclosed
CN-119823040-A Preparation method of amido-containing 3, 4-dihydro-isoquinoline-1 (2H) -ketone derivative 浙江理工大学嵊州创新研究院有限公司 2025-04-15 CN disclosed
CN-119816493-A Multivalent fibroblast activation protein ligand for targeted delivery applications 菲罗化学股份公司 2025-04-11 CN disclosed
US-12264156-B2 Compounds and pharmaceutical compositions thereof for the treatment of diseases GALAPAGOS NV (BE) 2025-04-01 US disclosed
CN-119698418-A Heterocyclic compounds, compositions thereof and methods of treatment therewith 百济神州(苏州)生物科技有限公司 2025-03-25 CN disclosed
CN-113999249-B Methods for preparing tricyclic PI3K inhibitor compounds and methods of treating cancer using the same 基因泰克公司 2025-03-25 CN disclosed
CN-119633858-A Near infrared light mediated heterogeneous composite photocatalyst and preparation method and application thereof 浙江工业大学台州研究院 2025-03-18 CN disclosed
CN-119638696-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2025-03-18 CN disclosed
EP-4514784-A1 ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE Petra Pharma Corporation (US) 2025-03-05 EP disclosed
CN-119528905-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2025-02-28 CN disclosed
CN-119546615-A Sonrotoclax intermediates and process for their preparation 百济神州(苏州)生物科技有限公司 2025-02-28 CN disclosed
CN-119504705-A Non-peptide somatostatin 5 receptor agonists and uses thereof 克林提克斯医药股份有限公司 2025-02-25 CN disclosed
CN-119506909-A Method for electrochemically synthesizing 3, 4-dihydro-isoquinoline-1 (2H) -ketone compound 宜宾学院 2025-02-25 CN disclosed
CN-115872930-B N-substituted 3, 4-dihydro-isoquinolin-1 (2H) -one derivatives, compositions thereof and use thereof in medicine 贵州医科大学 2025-02-11 CN disclosed
US-12221416-B2 Antagonists of human integrin α4β7 MORPHIC THERAPEUTIC, INC. (US) 2025-02-11 US disclosed
CN-119384412-A SARM1 modulators, their preparation and use 维泰瑞隆有限公司 2025-01-28 CN disclosed
WO-2025017305-A1 MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE REDX PHARMA LIMITED (GB) 2025-01-23 WO disclosed
WO-2025019585-A1 KINASE INHIBITORS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2025-01-23 WO disclosed
CN-119320388-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2025-01-17 CN disclosed
CN-114195764-B Compound serving as thyroid hormone beta receptor agonist and application thereof 广东东阳光药业股份有限公司 2025-01-17 CN disclosed
CN-114269729-B Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith 细胞基因公司 2025-01-17 CN disclosed
CN-119301106-A Allosteric benzopyrone inhibitors of phosphoinositide 3-kinase (PI 3K) for the treatment of disease 佩特拉制药公司 2025-01-10 CN disclosed
CN-119301124-A Ketal protected intermediates for Sonrotoclax and methods of making the same 百济神州(苏州)生物科技有限公司 2025-01-10 CN disclosed
EP-4050006-B1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO LTD (KR) 2025-01-01 EP disclosed
EP-4476204-A1 COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS Theras, Inc. (US) 2024-12-18 EP disclosed
US-20240408081-A1 NOVEL SYNERGISTIC COMBINATIONS AND METHODS OF USE THEREOF FOR TREATING CANCERS INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE - INSERM (FR) 2024-12-12 US disclosed
CN-114585614-B Non-peptide somatostatin 5 receptor agonists and uses thereof 克林提克斯医药股份有限公司 2024-12-03 CN disclosed
CN-119013265-A GLUT9 heterocyclic inhibitors for the treatment of disease 爱尔兰好利恩治疗有限公司 2024-11-22 CN disclosed
US-20240383913-A1 THIOPHENE RING COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SHANGHAITECH UNIVERSITY (CN) 2024-11-21 US disclosed
US-20240376084-A1 INHIBITORS OF ALPHA-HEMOLYSIN OF STAPHYLOCOCCUS AUREUS HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE) 2024-11-14 US disclosed
US-20240368173-A1 TRICYCLIC GPR65 MODULATORS Pathios Therapeutics Limited (GB) 2024-11-07 US disclosed
CN-118894816-A 3, 3-Difluoroallylamine or salt thereof and pharmaceutical composition comprising the same 柳韩洋行 2024-11-05 CN disclosed
EP-4249481-A4 DIHYDROISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AND USES THEREOF Hefei Institutes of Physical Science, Chinese Academy of Sciences (CN) 2024-10-30 EP disclosed
EP-4448513-A1 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF BeiGene Switzerland GmbH (CH) 2024-10-23 EP disclosed
EP-4448513-A1 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF BeiGene Switzerland GmbH (CH) 2024-10-23 EP disclosed
CN-118812532-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2024-10-22 CN disclosed
CN-118791431-A Dihydro-isoquinolone compounds and isoindoles Selective synthesis method of pinone compound 常州大学 2024-10-18 CN disclosed
US-20240343704-A1 HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2024-10-17 US disclosed
CN-118754852-A Novel dihydroisoquinolinones and application thereof in preparing bactericide for resisting plant pathogenic fungi 西南交通大学 2024-10-11 CN disclosed
CN-113453681-B Substituted 3- ((3-aminophenyl) amino) piperidine-2, 6-dione compounds, compositions thereof, and methods of treatment using the same 细胞基因公司 2024-10-11 CN disclosed
CN-118724867-A Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith 细胞基因公司 2024-10-01 CN disclosed
CN-118679163-A Bicyclic heteroaryl compounds and uses thereof 上海奕拓医药科技有限责任公司 2024-09-20 CN disclosed
US-20240299322-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES LANTERN PHARMA INC. (US) 2024-09-12 US disclosed
US-20240287022-A1 IL4I1 INHIBITORS AND METHODS OF USE MERCK SHARP & DOHME LLC (US) 2024-08-29 US disclosed
CN-118556062-A Compounds, pharmaceutical compositions and methods for treating, preventing or managing hyperproliferative disorders 文赛克斯制药有限责任公司 2024-08-27 CN disclosed
CN-118401514-A 3, 4-Dihydroisoquinolin-1 (2H) -one derivatives as STING antagonists and uses thereof 百济神州有限公司 2024-07-26 CN disclosed
CN-118401514-A 3, 4-Dihydroisoquinolin-1 (2H) -one derivatives as STING antagonists and uses thereof 百济神州有限公司 2024-07-26 CN disclosed
CN-118359612-A Compounds and pharmaceutical compositions for the treatment of diseases 加拉帕戈斯股份有限公司 2024-07-19 CN disclosed
CN-118344338-A Substituted 4-aminoisoindoline-1, 3-dione compounds and their use for the treatment of lymphomas 细胞基因公司 2024-07-16 CN disclosed
CN-118284692-A Gene editing of PCSK9 or ANGPTL3 and compositions and methods of using same for treating diseases 维乎医疗有限公司 2024-07-02 CN disclosed
CN-113330001-B 3, 3-Difluoroallylamine or salt thereof and pharmaceutical composition comprising the same 柳韩洋行 2024-07-02 CN disclosed
WO-2024125464-A1 TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) 2024-06-20 WO disclosed
US-20240182468-A1 COMPOUNDS FOR THE ACTIVATION OF AMPK PFIZER (US) 2024-06-06 US disclosed
EP-4376822-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES Lantern Pharma Inc. (US) 2024-06-05 EP disclosed
CN-114957212-B Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith 细胞基因公司 2024-05-24 CN disclosed
EP-4367123-A1 PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS Glenmark Specialty S.A. (CH) 2024-05-15 EP disclosed
CN-116615417-B 1, 4-Diheterocyclic group substituted aromatic ring or aromatic heterocyclic compound and application thereof 广州必贝特医药股份有限公司 2024-05-14 CN disclosed
CN-115093369-B Synthesis method of 3, 4-dihydro-isoquinoline-1-ketone compound 浙大城市学院 2024-05-10 CN disclosed
CN-118019735-A Arylsulfonyl compounds as CCR6 inhibitors 坎莫森特里克斯公司 2024-05-10 CN disclosed
CN-117946098-A Pyrimidine PLK1 inhibitor and preparation method and application thereof 上海深势唯思科技有限责任公司 2024-04-30 CN disclosed
CN-117946093-A Compounds useful as HPK1 inhibitors 深圳福沃药业有限公司 2024-04-30 CN disclosed
CN-117916368-A Base editing of thyroxine transporter genes 比姆医疗股份有限公司 2024-04-19 CN disclosed
WO-2024006956-A9 DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2024-04-11 WO disclosed
CN-115260096-B Method for synthesizing dihydroisoquinolinones based on carbon monoxide gas or carbon monoxide substitution source 武汉大学 2024-04-09 CN disclosed
CN-110637015-B Fanisole X receptor agonist and application thereof 奥加诺沃公司 2024-04-02 CN disclosed
CN-114031553-B Preparation method of 4- [ (methoxyacyl) methyl ] -3, 4-dihydro-isoquinoline-1 (2H) -ketone compound 郑州师范学院 2024-03-22 CN disclosed
CN-114031553-B Preparation method of 4- [ (methoxyacyl) methyl ] -3, 4-dihydro-isoquinoline-1 (2H) -ketone compound 郑州师范学院 2024-03-22 CN disclosed
CN-113544186-B Organic semiconductor composition 天光材料科技股份有限公司 2024-03-19 CN disclosed
CN-117730083-A Pyrimidine compounds as MAP4K1 inhibitors 格兰马克专业公司 2024-03-19 CN disclosed
EP-4330246-A1 HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) Ontario Institute for Cancer Research (OICR) (CA) 2024-03-06 EP disclosed
CN-111194215-B Methods and compositions for modulating splicing 斯基霍克疗法公司 2024-03-01 CN disclosed
CN-117597340-A Substituted amino-aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) 安大略省癌症研究所(OICR) 2024-02-23 CN disclosed
CN-117597336-A Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) 安大略省癌症研究所(OICR) 2024-02-23 CN disclosed
CN-115515947-B SHP2 inhibitor, composition and application thereof 贝达药业股份有限公司 2024-02-06 CN disclosed
CN-107915661-B Organic semiconductor compound 天光材料科技股份有限公司 2024-01-23 CN disclosed
WO-2024016014-A2 METHOD FOR TREATING BREAST CANCERS AND PARP RESISTANT BREAST CANCERS LANTERN PHARMA INC. (US) 2024-01-18 WO disclosed
CN-117377495-A Non-peptide targeted therapeutic agent and use thereof 克林提克斯医药股份有限公司 2024-01-09 CN disclosed
CN-117377669-A TYK2 inhibitor and application thereof 苏多生物科学有限公司 2024-01-09 CN disclosed
CN-117337289-A Tetracyclic compounds for the treatment of brain disorders 加利福尼亚大学董事会 2024-01-02 CN disclosed
CN-111886233-B Triazolone derivatives or salts thereof and pharmaceutical compositions containing the same 柳韩洋行 2024-01-02 CN disclosed
CN-117242073-A PRMT5 inhibitors and uses thereof 海思科医药集团股份有限公司 2023-12-15 CN disclosed
CN-117242072-A TYK2 inhibitor and application thereof 苏多生物科学有限公司 2023-12-15 CN disclosed
WO-2023240134-A1 SUBSTITUTED 3,4-DIHYDROISOQUINOLIN-1(2H)-ONE DERIVATIVES AND RELATED USES NodThera Limited (GB) 2023-12-14 WO disclosed
WO-2023236920-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2023-12-14 WO disclosed
CN-113471251-B Display assembly, display device and driving method 华为技术有限公司 2023-12-08 CN disclosed
CN-108148073-B Organic semiconductor compound 天光材料科技股份有限公司 2023-12-08 CN disclosed
CN-111315796-B Organic semiconductor compound 天光材料科技股份有限公司 2023-11-24 CN disclosed
CN-117120440-A TYK2 inhibitor and application thereof 苏多生物科学有限公司 2023-11-24 CN disclosed
CN-114989085-B Aryl lactam ring compound, pharmaceutical composition and application thereof 安徽医科大学 2023-11-24 CN disclosed
CN-111566089-B IRE1 small molecule inhibitors 康奈尔大学 2023-11-17 CN disclosed
CN-117062816-A Tricyclic-amide-bicyclic PRMT5 inhibitors 美国安进公司 2023-11-14 CN disclosed
WO-2023212693-A1 ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE PETRA PHARMA CORPORATION (US) 2023-11-02 WO disclosed
CN-116917278-A Divalent fibroblast activation protein ligands for targeted delivery applications 菲罗化学股份公司 2023-10-20 CN disclosed
CN-116888120-A PRMTS inhibitors 美国安进公司 2023-10-13 CN disclosed
EP-4249481-A1 DIHYDROISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AND USES THEREOF Hefei Institutes of Physical Science, Chinese Academy of Sciences (CN) 2023-09-27 EP disclosed
CN-116806218-A Sulfonamide and its use for the treatment of parasitic helminth infections and diseases 新基公司 2023-09-26 CN disclosed
CN-112352328-B Organic semiconductor compound 天光材料科技股份有限公司 2023-09-22 CN disclosed
CN-114262294-B Phenyl isoquinoline alkaloid compound and preparation method and application thereof 成都中医药大学 2023-09-22 CN disclosed
CN-116789726-A Steroid compound, preparation method and application thereof 珂阑(上海)医药科技有限公司 2023-09-22 CN disclosed
CN-116783191-A Tricyclic carboxamide derivatives as PRMT5 inhibitors 美国安进公司 2023-09-19 CN disclosed
CN-116745264-A Methods and compositions for KRAS modification 2692372安大略公司 2023-09-12 CN disclosed
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CN-116600801-A HSD17B13 inhibitors and uses thereof FL2022-001公司 2023-08-15 CN disclosed
CN-116583303-A Tripterine conjugates and uses thereof 瑞阳公司 2023-08-11 CN disclosed
CN-116547282-A Heterocyclic compounds and their use for the treatment of helminth infections and diseases 新基公司 2023-08-04 CN disclosed
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CN-116514824-A Tri-ring compound, preparation method and application thereof 上海科技大学 2023-08-01 CN disclosed
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CN-116507608-A Compounds, compositions, and methods 戴纳立制药公司 2023-07-28 CN disclosed
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CN-116438180-A Tricyclic neural plasticizers and uses thereof 德力克斯疗法有限公司 2023-07-14 CN disclosed
CN-112236882-B Organic semiconductor compound 天光材料科技股份有限公司 2023-06-30 CN disclosed
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WO-2023109912-A1 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF BEIGENE, LTD. (KY) 2023-06-22 WO disclosed
CN-110177783-B Hormone receptor modulators for the treatment of metabolic conditions and disorders 阿德利克斯股份有限公司 2023-06-06 CN disclosed
CN-116157398-A 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy 意大发马克股份公司 2023-05-23 CN disclosed
CN-116096429-A Base editing of PCSK9 and methods of use thereof for treating diseases 维乎医疗有限公司 2023-05-09 CN disclosed
CN-116096883-A Base editing of ANGPTL3 and methods of treating diseases using the same 维乎医疗有限公司 2023-05-09 CN disclosed
US-11638706-B2 Methods for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2023-05-02 US disclosed
EP-4168399-A1 COMPOUNDS AND THEIR USES AS MIF INHIBITORS Nanjing Immunophage Biotech Co., Ltd. (CN) 2023-04-26 EP disclosed
CN-115968293-A Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment 新基公司 2023-04-14 CN disclosed
CN-115955979-A Cereblan binding compounds, compositions thereof, and methods for treatment thereof 新基公司 2023-04-11 CN disclosed
CN-115872930-A N-substituted 3,4-dihydroisoquinoline-1 (2H) -ketone derivative, composition thereof and application thereof in medicines 贵州医科大学 2023-03-31 CN disclosed
CN-111825656-B Inhibitors of protein arginine methyltransferase 5 (PRMT 5), pharmaceutical products thereof, and methods thereof 南京药石科技股份有限公司 2023-03-31 CN disclosed
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CN-115835866-A Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment 新基公司 2023-03-21 CN disclosed
US-11608501-B2 Methods for modifying RNA splicing PTC THERAPEUTICS, INC. (US) 2023-03-21 US disclosed
WO-2023010119-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES LANTERN PHARMA INC. (US) 2023-02-02 WO disclosed
CN-110294742-B Fused ring ASK1 inhibitor and application thereof 山东轩竹医药科技有限公司 2023-01-31 CN disclosed
US-20230026466-A1 WDR5 INHIBITORS AND MODULATORS VANDERBILT UNIVERSITY 2023-01-26 US disclosed
US-20230023140-A1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2023-01-26 US disclosed
US-20230017532-A1 NOVEL IMIDAZOPYRAZINE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2023-01-19 US disclosed
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CN-115515947-A SHP2 inhibitor and composition and application thereof 贝达药业股份有限公司 2022-12-23 CN disclosed
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CN-115397412-A Modulators of MAS-related G protein receptor X4 and related products and methods 伊赛恩特制药公司 2022-11-25 CN disclosed
CN-115286557-A Preparation method of 3-alkenyl isoindoline-1-ketone derivative and prepared derivative 宿州学院 2022-11-04 CN disclosed
WO-2022226665-A1 HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2022-11-03 WO disclosed
WO-2022226668-A1 HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2022-11-03 WO disclosed
EP-4076459-A1 PRMT5 INHIBITORS Merck Sharp & Dohme LLC (US) 2022-10-26 EP disclosed
WO-2022206964-A1 PRMT5 INHIBITOR AND USE THEREOF 海思科医药集团股份有限公司 2022-10-06 WO disclosed
CN-115093369-A Synthetic method of 3, 4-dihydroisoquinoline-1-ketone compound 浙大城市学院 2022-09-23 CN disclosed
US-20220289732-A1 HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS NOVARTIS AG (CH) 2022-09-15 US disclosed
EP-4055013-A1 WDR5 INHIBITORS AND MODULATORS Vanderbilt University (US) 2022-09-14 EP disclosed
CN-115052627-A IRAK degrading agents and uses thereof 凯麦拉医疗公司 2022-09-13 CN disclosed
CN-114989085-A Aryl lactam ring compound, pharmaceutical composition and application thereof 安徽医科大学 2022-09-02 CN disclosed
CN-114957212-A Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith 细胞基因公司 2022-08-30 CN disclosed
CN-114945562-A Bicyclic compounds and uses thereof 爱思开生物制药株式会社 2022-08-26 CN disclosed
WO-2022173849-A1 (HETERO)ARYLAMINO-CYCLOHEXYL-SULFONYL DERIVATIVES AS CCR6 INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2022-08-18 WO disclosed
CN-114829344-A Novel pyrimidine derivative and use thereof 韩国化学研究院 2022-07-29 CN disclosed
CN-114698370-A Compounds and methods for treating cytokine release syndrome 里格尔药品股份有限公司 2022-07-01 CN disclosed
EP-4010334-A1 HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS Novartis AG (CH) 2022-06-15 EP disclosed
CN-109069512-B Substituted aminopurine compounds, compositions thereof, and related methods of treatment 西格诺药品有限公司 2022-06-14 CN disclosed
CN-109476696-B Anti-trypanosome and anti-leishmania agents for animals and humans 细胞基因公司 2022-06-10 CN disclosed
CN-114516856-A Dihydroisoquinolinone and isoindolinone derivatives and uses thereof 中国科学院合肥物质科学研究院 2022-05-20 CN disclosed
CN-114262294-A Phenylisoquinoline alkaloid compound and preparation method and application thereof 成都中医药大学 2022-04-01 CN disclosed
CN-114269729-A Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith 细胞基因公司 2022-04-01 CN disclosed
CN-109563094-B (hetero) aryl-substituted piperidinyl derivatives, process for their preparation and pharmaceutical compositions containing them 法国施维雅药厂 2022-03-18 CN disclosed
CN-114195764-A Compound as thyroid hormone beta receptor agonist and application thereof 广东东阳光药业有限公司 2022-03-18 CN disclosed
US-20220081422-A1 DIHYDROOROTATE DEHYDROGENASE INHIBITORS JANSSEN BIOTECH, INC. 2022-03-17 US disclosed
CN-114007611-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2022-02-01 CN disclosed
CN-114007611-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2022-02-01 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (24 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132132-A1 3A,4,5,6-TETRAHYDRO-1 H-PYRAZOLO[3,4-C]PYRIDIN-7(7AH)-ONE DERIVATIVES AS FACTOR XIIA INHIBITORS F11, F13B, F7 PARP10 1988/4885PARP1 462/4885PARP11 294/4885
US-20250161247-A1 METHOD FOR TREATING BREAST CANCERS AND PARP RESISTANT BREAST CANCERS PARP1, PARP2, PARP3 PARP10 14/4885PARP1 1/4885PARP11 4/4885
US-20240182468-A1 COMPOUNDS FOR THE ACTIVATION OF AMPK PRKAG1, PRKAG2, PRKAB1 PARP10 620/4885PARP1 512/4885PARP11 470/4885
US-20250320184-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SARM1, SMN1; SMN2, ADRM1 PARP10 697/4885PARP1 943/4885PARP11 428/4885
US-20240368173-A1 TRICYCLIC GPR65 MODULATORS GPR65, GPR3, NR1H2 PARP10 970/4885PARP1 4106/4885PARP11 2055/4885
US-20220081422-A1 DIHYDROOROTATE DEHYDROGENASE INHIBITORS DHODH, DLD, DPYD PARP10 806/4885PARP1 1458/4885PARP11 997/4885
US-12391674-B2 Heterocyclic compounds for the treatment of epilepsy SLC6A11, SCN1A, SCN1B PARP10 4400/4885PARP1 4570/4885PARP11 3742/4885
US-20240299322-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES PARP1, PARP2, PARP11 PARP10 8/4885PARP1 1/4885PARP11 3/4885
US-20230023140-A1 BICYCLIC COMPOUND AND USE THEREOF PRMT5, PRMT6, PRMT1 PARP10 58/4885PARP1 205/4885PARP11 63/4885
US-20220402911-A1 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES IL1A, TNF, IL6 PARP10 2139/4885PARP1 2937/4885PARP11 2707/4885
US-12221416-B2 Antagonists of human integrin α4β7 ITGB7, ITGB4, ITGA4 PARP10 1124/4885PARP1 2259/4885PARP11 1851/4885
US-20230026466-A1 WDR5 INHIBITORS AND MODULATORS WDR5, WDR1, WDR3 PARP10 482/4885PARP1 1578/4885PARP11 510/4885
US-12264156-B2 Compounds and pharmaceutical compositions thereof for the treatment of diseases TNF, IL1A, COL1A1 PARP10 2425/4885PARP1 2964/4885PARP11 2799/4885
US-12637461-B2 Compounds for the activation of AMPK PRKAG1, PRKAB1, PRKAA1 PARP10 546/4885PARP1 537/4885PARP11 308/4885
US-12331035-B2 Bicyclic compound and use thereof PRMT5, PRMT6, PRMT1 PARP10 58/4885PARP1 205/4885PARP11 63/4885
US-20250178999-A1 ONE STEP SYNTHESIS OF 1-TETRALONE COMPOUNDS AND USES THEREOF IN THE PREPARATION OF (+)-TETRALONE ABSCISIC ACID (ABA) AAK1, ACSL1, COASY PARP10 4521/4885PARP1 3829/4885PARP11 3356/4885
US-20220289732-A1 HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS WDR5, WDR77, WDR1 PARP10 512/4885PARP1 1292/4885PARP11 326/4885
US-20240376084-A1 INHIBITORS OF ALPHA-HEMOLYSIN OF STAPHYLOCOCCUS AUREUS SERPINB1, LTA, SERPINC1 PARP10 3970/4885PARP1 4191/4885PARP11 3593/4885
US-20240383913-A1 THIOPHENE RING COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF TACR1, HTR1F, TPH1 PARP10 3218/4885PARP1 4178/4885PARP11 2465/4885
US-20230017532-A1 NOVEL IMIDAZOPYRAZINE DERIVATIVES MRPL21, O60361, MYD88 PARP10 3083/4885PARP1 2724/4885PARP11 1435/4885
US-11608501-B2 Methods for modifying RNA splicing RBM17, SNRPA1, SNRPE PARP10 1660/4885PARP1 3428/4885PARP11 1952/4885
US-20240287022-A1 IL4I1 INHIBITORS AND METHODS OF USE IL4I1, IL4, IL1RN PARP10 3657/4885PARP1 4531/4885PARP11 3233/4885
US-20240343704-A1 HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) CMPK1, WNK1, AAK1 PARP10 2072/4885PARP1 2516/4885PARP11 1176/4885
US-11638706-B2 Methods for treating Huntington's disease HTT, HYPK, FH PARP10 3382/4885PARP1 3055/4885PARP11 2887/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.