Sugi Predict

Sugi Predict / Compounds / SCHEMBL11601201

SCHEMBL11601201

SCHEMBL11601201

COC(=O)c1ccc(C(=O)OC)c(CBr)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 15/20 0.57
▸ ALDH1A1 P00352 13/20 0.57
▸ HPGD P15428 6/20 0.57
▸ MAPT P10636 4/20 0.57
▸ HSD17B10 Q99714 4/20 0.57
▸ GLA P06280 3/20 0.57
▸ GAA P10253 3/20 0.57
▸ ATM Q13315 3/20 0.57
▸ CASP1 P29466 1/20 0.57
▸ CASP7 P55210 1/20 0.57
▸ LMNA P02545 4/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ KMT2A Q03164 1/20 0.49
▸ CA12 O43570 1/20 0.49
▸ CA1 P00915 1/20 0.49
▸ CA2 P00918 1/20 0.49
▸ CA7 P43166 1/20 0.49
▸ XDH P47989 1/20 0.49
▸ CA9 Q16790 1/20 0.49
▸ CA14 Q9ULX7 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30832832 1.00 KDM4E (0.57) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL23906982 0.90 KDM4E (0.47) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL2065651 0.86 KDM4E (0.53) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL29559628 0.86 CA1 (0.52) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL1028046 0.86 CA1 (0.52) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL12796984 0.86 KDM4E (0.62) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL16938242 0.84 CA1 (0.50) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL8482173 0.84 KDM4E (0.59) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL8482179 0.84 KDM4E (0.59) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL7844337 0.83 KDM4E (0.57) KDM4EALDH1A1HPGDMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118206529-A Dihydrobenzimidazolone C4医药公司 2024-06-18 — — CN disclosed
US-20240109889-A1 DIHYDROBENZIMIDAZOLONES FOR MEDICAL TREATMENT C4 THERAPEUTICS, INC. (US) 2024-04-04 — — US disclosed
CN-111315735-B Dihydrobenzimidazolone C4医药公司 2024-03-08 — — CN disclosed
US-11787802-B2 Dihydrobenzimidazolones for medical treatment C4 THERAPEUTICS, INC. (US) 2023-10-17 — — US disclosed
US-20230257365-A1 SMALL MOLECULE ANDROGEN RECEPTOR PROTEIN DEGRADERS UNIV MICHIGAN REGENTS (US) 2023-08-17 — — US disclosed
US-20230257365-A1 SMALL MOLECULE ANDROGEN RECEPTOR PROTEIN DEGRADERS UNIV MICHIGAN REGENTS (US) 2023-08-17 — — US disclosed
US-20230257365-A1 SMALL MOLECULE ANDROGEN RECEPTOR PROTEIN DEGRADERS UNIV MICHIGAN REGENTS (US) 2023-08-17 — — US disclosed
US-20220289738-A1 DIHYDROBENZIMIDAZOLONES FOR MEDICAL TREATMENT C4 THERAPEUTICS, INC. (US) 2022-09-15 — — US disclosed
US-11254672-B2 Dihydrobenzimidazolones for medical treatment C4 THERAPEUTICS, INC. (US) 2022-02-22 — — US disclosed
WO-2022011204-A1 SMALL MOLECULE ANDROGEN RECEPTOR PROTEIN DEGRADERS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2022-01-13 — — WO disclosed
US-4112114-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1978-09-05 — — US disclosed
US-4100174-A Process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids and intermediates SYNTEX (U.S.A.) INC. (US) 1978-07-11 — — US disclosed
US-4051260-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1977-09-27 — — US disclosed
US-4041173-A ANTI-ASTHMATIC AGENTS SYNTEX (U.S.A.) INC. (US) 1977-08-09 — — US disclosed
US-4038299-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1977-07-26 — — US disclosed
US-4035509-A ANTIALLERGENS SYNTEX (U.S.A.) INC. (US) 1977-07-12 — — US disclosed
US-4020094-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1977-04-26 — — US disclosed
US-4011241-A An intermediate in the preparation of 2-(5H-dibenzo[a,d]cyclophepten-5-on-2-yl)acetic, propionic and butyric acids SYNTEX (U.S.A.) INC. (US) 1977-03-08 — — US disclosed
US-3975540-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1976-08-17 — — US disclosed
US-3966820-A ANALGESICS, ANTIINFLAMMATORY, ANTIPYRETICS SYNTEX (U.S.A.) INC. (US) 1976-06-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257365-A1 SMALL MOLECULE ANDROGEN RECEPTOR PROTEIN DEGRADERS AR, SHBG, CYP19A1 KDM4E 1743/4885ALDH1A1 242/4885HPGD 3456/4885
US-20240109889-A1 DIHYDROBENZIMIDAZOLONES FOR MEDICAL TREATMENT CRBN, CUL4A, ADRM1 KDM4E 864/4885ALDH1A1 2009/4885HPGD 3006/4885
US-20220289738-A1 DIHYDROBENZIMIDAZOLONES FOR MEDICAL TREATMENT CRBN, CUL4A, ADRM1 KDM4E 864/4885ALDH1A1 2009/4885HPGD 3006/4885
US-11787802-B2 Dihydrobenzimidazolones for medical treatment CRBN, CUL4A, ADRM1 KDM4E 864/4885ALDH1A1 2009/4885HPGD 3006/4885
US-11254672-B2 Dihydrobenzimidazolones for medical treatment CRBN, CUL4A, ADRM1 KDM4E 864/4885ALDH1A1 2009/4885HPGD 3006/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.