Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11602008 | 0.83 | FFAR4 (0.69) | GPR84FFAR4FFAR1FAAH | |
| SCHEMBL11602265 | 0.83 | ACE2 (0.51) | GPR84FFAR4FFAR1ACE2FAAH | |
| SCHEMBL11601264 | 0.83 | FFAR4 (0.69) | GPR84FFAR4FFAR1FAAH | |
| SCHEMBL11602010 | 0.83 | FFAR4 (0.69) | GPR84FFAR4FFAR1FAAH | |
| SCHEMBL4964157 | 0.83 | FFAR4 (0.69) | GPR84FFAR4FFAR1FAAH | |
| SCHEMBL11784233 | 0.82 | GPR84 (0.51) | GPR84FFAR4FFAR1ACE2FAAH | |
| SCHEMBL11792806 | 0.81 | GPR84 (0.50) | GPR84FFAR4FFAR1ACE2FAAH | |
| SCHEMBL11799508 | 0.80 | GPR84 (0.49) | GPR84FFAR4FFAR1ACE2FAAH | |
| SCHEMBL11603929 | 0.79 | FFAR4 (0.43) | GPR84FFAR4FFAR1FAAHNFKB1 | |
| SCHEMBL11603619 | 0.78 | FFAR1 (0.44) | GPR84FFAR4FFAR1FAAHNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4091107-A | RENAL VASODILATORS, ANTICLOTTING AGENTS, GROWTH HORMONE RELEASE, REGULATORS OF IMMUNE RESPONSE | MERCK & CO., INC. (US) | 1978-05-23 | — | — | US | disclosed |
| US-4033996-A | RENAL VASODILATORS, ANTITHROMBOSIS, GROWTH HORMONE RELEASING | MERCK & CO., INC. (US) | 1977-07-05 | — | — | US | disclosed |