Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 8/20 | 0.58 |
| ▸ | MMP9 | P14780 | 8/20 | 0.58 |
| ▸ | MMP8 | P22894 | 7/20 | 0.58 |
| ▸ | MMP13 | P45452 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11607926 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2NPSR1MMP2MMP9MMP8 | |
| SCHEMBL11607483 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2NPSR1MMP2MMP9MMP8 | |
| SCHEMBL11608475 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2NPSR1MMP2MMP9MMP8 | |
| SCHEMBL11606565 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2NPSR1MMP2MMP9MMP8 | |
| SCHEMBL11607319 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2NPSR1MMP2MMP9MMP8 | |
| SCHEMBL542639 | 0.76 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1MMP2MMP9MMP8 | |
| SCHEMBL5443745 | 0.75 | MMP2 (0.70) | SMN1; SMN2NPSR1MMP2MMP9MMP8 | |
| SCHEMBL9050747 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2NPSR1MMP2MMP9MMP8 | |
| SCHEMBL2138557 | 0.74 | PDE7A (0.46) | SMN1; SMN2NPSR1MMP2MMP9LMNA | |
| SCHEMBL1971074 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4110470-A | Pharmaceutical composition comprising d,l-α-methyl-thyroxine ethyl ester and the salts thereof and the control of cholesterol and triglyceride blood level therewith | KUMMER HORST | 1978-08-29 | — | — | US | disclosed |