Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11608397 | 0.78 | KMT2A (0.46) | HTR6PDE10AKMT2AKDM4EALDH1A1 | |
| SCHEMBL11604789 | 0.76 | PDE10A (0.35) | PDE10AKMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL11606253 | 0.76 | ELANE (0.38) | PDE10AKMT2AKDM4EMEN1KDM4D | |
| SCHEMBL11603925 | 0.76 | PDE10A (0.42) | PDE10AKMT2AHPGDKDM4EALDH1A1 | |
| SCHEMBL11604755 | 0.76 | SYK (0.36) | HTR6PDE10AKMT2AKDM4EMEN1 | |
| SCHEMBL11608018 | 0.76 | ALDH1A1 (0.34) | PDE10AALDH1A1 | |
| SCHEMBL11606693 | 0.74 | MEN1 (0.38) | KMT2AHPGDMEN1L3MBTL1 | |
| SCHEMBL11602446 | 0.72 | ACP1 (0.38) | KMT2AKDM4EALDH1A1NPSR1MEN1 | |
| SCHEMBL11604780 | 0.71 | FAAH (0.37) | HPGDKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL11605002 | 0.71 | APP (0.41) | KMT2AHPGDKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4072680-A | Derivatives of pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine | E. R. SQUIBB & SONS, INC. (US) | 1978-02-07 | — | — | US | disclosed |