Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11604271 | 0.80 | HTT (0.39) | KMT2AKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL11605005 | 0.80 | NPC1 (0.38) | KMT2ARXFP1ALDH1A1HTTMEN1 | |
| SCHEMBL11605000 | 0.78 | HTR6 (0.36) | KMT2AKDM4EALDH1A1NPSR1HTR6 | |
| SCHEMBL11595463 | 0.72 | KMT2A (0.43) | KMT2ARXFP1KDM4EALDH1A1NPSR1 | |
| SCHEMBL21917609 | 0.68 | L3MBTL1 (0.42) | RXFP1KDM4EALDH1A1HTTPDE10A | |
| SCHEMBL11431652 | 0.65 | KMT2A (0.35) | KMT2ARXFP1KDM4EALDH1A1NPSR1 | |
| SCHEMBL16695720 | 0.65 | PARP1 (0.63) | KMT2AKDM4EALDH1A1MEN1KDM4D | |
| SCHEMBL20561458 | 0.64 | PDE10A (0.36) | KDM4EALDH1A1HTTPDE10AL3MBTL1 | |
| SCHEMBL21917537 | 0.64 | KDM4E (0.41) | KMT2AKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL22520937 | 0.63 | KMT2A (0.53) | KMT2AKDM4EALDH1A1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4072680-A | Derivatives of pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine | E. R. SQUIBB & SONS, INC. (US) | 1978-02-07 | — | — | US | disclosed |