Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11617978 | 0.85 | LMNA (0.46) | LMNATP53SMN1; SMN2KMT2AMAPT | |
| SCHEMBL11615733 | 0.79 | MAPT (0.59) | SMN1; SMN2KMT2AMAPTALOX15P2RY14 | |
| SCHEMBL11613662 | 0.77 | SMN1; SMN2 (0.52) | TP53SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL11617148 | 0.76 | SMN1; SMN2 (0.42) | LMNATP53SMN1; SMN2KMT2AMAPT | |
| SCHEMBL11508868 | 0.75 | LMNA (0.45) | LMNATP53KMT2AMAPTMEN1 | |
| SCHEMBL11601121 | 0.75 | LMNA (0.56) | LMNATP53KMT2AMAPTALOX15 | |
| SCHEMBL11619002 | 0.74 | GAA (0.47) | KMT2AMAPTMEN1ALOX15RAB9A | |
| SCHEMBL11615637 | 0.73 | GAA (0.57) | LMNASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL12879193 | 0.72 | MMP2 (0.54) | SMN1; SMN2KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL11610558 | 0.72 | MAPT (0.50) | LMNATP53KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |