Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13991168 | 0.79 | PTGS2 (0.42) | SMN1; SMN2MAPTTP53KMT2AALDH1A1 | |
| SCHEMBL11612526 | 0.76 | LMNA (0.48) | SMN1; SMN2MAPTTP53POLBLMNA | |
| SCHEMBL11508675 | 0.75 | CASR (0.36) | KMT2AF2 | |
| SCHEMBL11615849 | 0.72 | HPGD (0.35) | TP53KMT2AHPGDMEN1ALDH1A1 | |
| SCHEMBL12467451 | 0.65 | MAPT (0.38) | SMN1; SMN2MAPTTP53POLBLMNA | |
| SCHEMBL6355877 | 0.63 | P2RX7 (0.76) | SMN1; SMN2MAPTTP53POLBKMT2A | |
| SCHEMBL27689316 | 0.63 | PTGS2 (0.45) | SMN1; SMN2POLBKMT2AMEN1KDM4E | |
| SCHEMBL28064172 | 0.63 | MAPT (0.36) | SMN1; SMN2MAPTTP53POLBKMT2A | |
| SCHEMBL17995370 | 0.63 | CHEK1 (0.58) | SMN1; SMN2MAPTTP53POLBLMNA | |
| SCHEMBL11298244 | 0.63 | F2 (0.42) | KMT2AHPGDMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |