Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11713927 | 0.89 | LMNA (0.34) | NPC1L3MBTL1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL11714702 | 0.87 | SRD5A2 (0.43) | NPC1SRD5A2ALOX15KMT2AHTT | |
| SCHEMBL11714962 | 0.86 | KMT2A (0.39) | ALDH1A1NPC1L3MBTL1SRD5A2MAPK1 | |
| SCHEMBL11711464 | 0.85 | MAPT (0.49) | ALDH1A1NPC1MAPK1KMT2AHTT | |
| SCHEMBL11716587 | 0.85 | MRGPRX4 (0.43) | NPC1SRD5A2KMT2AHPGDMAPT | |
| SCHEMBL11716253 | 0.85 | ALOX15 (0.43) | NPC1ALOX15KMT2AHTTMAPT | |
| SCHEMBL7678669 | 0.77 | NPC1 (0.41) | ALDH1A1NPC1L3MBTL1SRD5A2MAPK1 | |
| SCHEMBL11716106 | 0.76 | SRD5A2 (0.40) | SRD5A2ALOX15HTTHPGDTSHR | |
| SCHEMBL11769319 | 0.75 | KMT2A (0.34) | ALDH1A1L3MBTL1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL11715848 | 0.74 | LMNA (0.36) | ALDH1A1NPC1SRD5A2MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4048191-A | Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-13 | — | — | US | claimed |
| US-4119639-A | Preparation of 5-aroylpyrrole-2-acetic acid derivatives | MCNEIL LABORATORIES, INCORPORATED (US) | 1978-10-10 | — | — | US | disclosed |
| US-4048191-A | Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-13 | — | — | US | disclosed |