Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11716106 | 0.88 | SRD5A2 (0.40) | SRD5A2HPGDLMNATSHRALOX15 | |
| SCHEMBL11612945 | 0.87 | ALDH1A1 (0.39) | SRD5A2HPGDTSHRALOX15HTT | |
| SCHEMBL11713927 | 0.85 | LMNA (0.34) | HPGDLMNAPOLBMEN1NPC1 | |
| SCHEMBL11716253 | 0.84 | ALOX15 (0.43) | LMNAALOX15HTTMEN1NPC1 | |
| SCHEMBL11711464 | 0.82 | MAPT (0.49) | HPGDLMNAPOLBHTTMEN1 | |
| SCHEMBL11716587 | 0.82 | MRGPRX4 (0.43) | SRD5A2HPGDPOLBMEN1NPC1 | |
| SCHEMBL11769319 | 0.74 | KMT2A (0.34) | HPGDLMNATSHRMEN1MAPT | |
| SCHEMBL11714962 | 0.74 | KMT2A (0.39) | SRD5A2HPGDALOX15HTTMEN1 | |
| SCHEMBL11716400 | 0.71 | GAA (0.33) | HPGDLMNAMEN1NPC1MAPT | |
| SCHEMBL11716046 | 0.71 | ALOX15 (0.41) | LMNAALOX15HTTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4048191-A | Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-13 | — | — | US | disclosed |