Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.50 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166642 | 0.81 | ESR1 (0.61) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL11458259 | 0.80 | CHRNB4 (0.75) | CHRNB4CHRNA3 | |
| SCHEMBL115735 | 0.77 | ESR1 (0.69) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL3258716 | 0.77 | ESR1 (0.69) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL16701296 | 0.77 | ESR1 (0.69) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL11455586 | 0.77 | CHRNB4 (0.69) | CHRNB4CHRNA3 | |
| Bromide SCHEMBL3639072 | 0.76 | ESR1 (0.68) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL3634548 | 0.75 | IGF1R (0.47) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL11466396 | 0.73 | CHRNB4 (0.52) | CHRNB4CHRNA3GHSRHRH3 | |
| SCHEMBL3801089 | 0.73 | ESR1 (0.61) | ESR1ESR2MLNRNR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424839-A2 | A PROCESS FOR THE PREPARATION OF LASOFOXIFENE TARTRATE | Glenmark Generics Limited (IN) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125578-A2 | A PROCESS FOR THE PREPARATION OF LASOFOXIFENE TARTRATE | GLENMARK GENERICS LIMITED (IN) | 2010-11-04 | — | — | WO | disclosed |