Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 6/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116156 | 0.75 | CHRNB4 (0.50) | IGF1RALOX15ESR1ESR2DRD2 | |
| SCHEMBL115735 | 0.72 | ESR1 (0.69) | ESR1ESR2DRD2ADRA2CMLNR | |
| SCHEMBL16701296 | 0.72 | ESR1 (0.69) | ESR1ESR2DRD2ADRA2CMLNR | |
| SCHEMBL3258716 | 0.72 | ESR1 (0.69) | ESR1ESR2DRD2ADRA2CMLNR | |
| SCHEMBL6610063 | 0.72 | LTA4H (0.57) | LTA4HSLC6A2HTR2AHTR2BSLC6A3 | |
| Bromide SCHEMBL3639072 | 0.72 | ESR1 (0.68) | ESR1ESR2DRD2ADRA2CMLNR | |
| SCHEMBL11448511 | 0.70 | CHRNA3 (0.50) | LTA4HCHEK2 | |
| SCHEMBL4965391 | 0.68 | LTA4H (0.64) | LTA4HSLC6A2HTR2AHTR2BSLC6A3 | |
| SCHEMBL8476007 | 0.68 | LTA4H (0.55) | LTA4H | |
| SCHEMBL7327575 | 0.67 | LTA4H (0.60) | LTA4HNPY1RHTR2CHTR2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164836-A2 | METHOD FOR THE PREPARATION OF LASOFOXIFENE AND CRYSTALLINE INTERMEDIATES USED THEREIN | Zentiva, k.s. (CZ) | 2010-03-24 | — | — | EP | claimed |
| WO-2008145075-A2 | METHOD FOR THE PREPARATION OF LASOFOXIFENE AND CRYSTALLINE INTERMEDIATES USED THEREIN | ZENTIVA, A.S. (CZ) | 2008-12-04 | — | — | WO | claimed |