Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 8/20 | 0.56 |
| ▸ | ADRB1 known ✓ | P08588 | 8/20 | 0.56 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.56 |
| ▸ | HTR2B known ✓ | P41595 | 3/20 | 0.56 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.56 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.56 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.56 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.56 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.56 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.56 |
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11617432 | 1.00 | ADRB2 (0.56) | ADRB2ADRB1ADRB3CYP2D6SIGMAR1 | |
| SCHEMBL11623257 | 0.91 | ADRB2 (0.66) | ADRB2ADRB1ADRB3CYP2D6SIGMAR1 | |
| SCHEMBL11617427 | 0.86 | HCAR2 (0.48) | ADRB2ADRB1ADRB3CYP2D6SIGMAR1 | |
| Dexpropranolol SCHEMBL30158526 | 0.83 | CYP2D6 (0.81) | ADRB2ADRB1ADRB3CYP2D6SIGMAR1 | |
| Propranolol SCHEMBL28607754 | 0.83 | CYP2D6 (0.81) | ADRB2ADRB1ADRB3CYP2D6SIGMAR1 | |
| Fumaric Acid SCHEMBL11142306 | 0.75 | MEN1 (0.45) | ADRB2ADRB1ADRB3CYP2D6CYP1A2 | |
| Propranolol SCHEMBL28921627 | 0.75 | CYP2D6 (0.88) | ADRB2ADRB1ADRB3CYP2D6SIGMAR1 | |
| SCHEMBL11618874 | 0.74 | CYP2D6 (0.67) | ADRB2ADRB1ADRB3CYP2D6HTR1A | |
| SCHEMBL11621070 | 0.74 | CYP2D6 (0.57) | ADRB2ADRB1ADRB3CYP2D6SIGMAR1 | |
| Fumaric Acid SCHEMBL10670380 | 0.73 | ADRB2 (0.49) | ADRB2ADRB1ADRB3CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4073909-A | ADRENERGIC BLOCKING AGENTS, HYPOGLYCEMIC AGENTS, ANTILIPEMIC AGENTS | SANDOZ LTD. (CH) | 1978-02-14 | — | — | US | disclosed |