Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646158 | 0.78 | KDM4E (0.56) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8787198 | 0.77 | L3MBTL1 (0.64) | SMN1; SMN2L3MBTL1HTTKMT2AMEN1 | |
| SCHEMBL2962210 | 0.77 | HTR2A (0.56) | CHRM1L3MBTL1HTTKMT2AMEN1 | |
| SCHEMBL9223088 | 0.74 | ALDH1A1 (0.58) | SMN1; SMN2HTTKMT2APOLBCYP2C9 | |
| SCHEMBL7649327 | 0.74 | BRD4 (0.70) | SMN1; SMN2L3MBTL1KMT2AMEN1KDM4E | |
| SCHEMBL10891696 | 0.73 | KMT2A (0.57) | SMN1; SMN2KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL2386068 | 0.72 | KMT2A (0.73) | SMN1; SMN2L3MBTL1KMT2AMEN1POLB | |
| SCHEMBL2892860 | 0.71 | SLC6A2 (0.50) | SMN1; SMN2CHRM1L3MBTL1HTTKMT2A | |
| SCHEMBL5316252 | 0.70 | ALDH1A1 (0.53) | KMT2AMEN1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7869032 | 0.70 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4086268-A | 2-(2-Amino-4-chlorophenoxy)benzyl alcohol and diacetate derivative | G. D. SEARLE & CO. (US) | 1978-04-25 | — | — | US | claimed |
| US-4086268-A | 2-(2-Amino-4-chlorophenoxy)benzyl alcohol and diacetate derivative | G. D. SEARLE & CO. (US) | 1978-04-25 | — | — | US | disclosed |
| US-3997401-A | Microbial transformation of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine | G. D. SEARLE & CO. (US) | 1976-12-14 | — | — | US | disclosed |