SCHEMBL11618

SCHEMBL11618

Nc1ccc(OC(F)C(F)F)nc1.O=[N+]([O-])c1ccc(OCC(F)(F)F)nc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.44
NPSR1 Q6W5P4 1/20 0.44
HSPB1 P04792 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
RAB9A P51151 1/20 0.36
GAA P10253 1/20 0.35
POLB P06746 1/20 0.34
MAPK1 P28482 1/20 0.34
MEN1 O00255 1/20 0.34
PABPC1 P11940 1/20 0.34
KMT2A Q03164 1/20 0.34
GABRA5 P31644 1/20 0.34
ALDH1A1 P00352 2/20 0.33
EPHX2 P34913 1/20 0.32
HSP90AA1 P07900 1/20 0.32
CXCR5 P32302 1/20 0.32
APLNR P35414 1/20 0.32
CCR6 P51684 1/20 0.32
CYP1A2 P05177 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5799 0.82 HSPB1 (0.54) MAPTNPSR1HSPB1L3MBTL1RAB9A
SCHEMBL1590498 0.82 MAPT (0.59) MAPTNPSR1HSPB1L3MBTL1RAB9A
SCHEMBL29516441 0.75 L3MBTL1 (0.56) MAPTNPSR1L3MBTL1RAB9APOLB
SCHEMBL28979578 0.75 KDM4E (0.47) RAB9APOLBMEN1KMT2AALDH1A1
SCHEMBL10092 0.75 L3MBTL1 (0.56) MAPTNPSR1L3MBTL1RAB9APOLB
SCHEMBL3894432 0.75 MAPT (0.51) MAPTNPSR1HSPB1L3MBTL1RAB9A
Hydrochloric Acid SCHEMBL1496776 0.74 L3MBTL1 (0.54) MAPTNPSR1L3MBTL1RAB9APOLB
SCHEMBL28723950 0.72 MAPT (0.53) MAPTNPSR1HSPB1L3MBTL1RAB9A
SCHEMBL558792 0.71 HSPB1 (0.56) MAPTNPSR1HSPB1L3MBTL1RAB9A
SCHEMBL29974305 0.71 HSPB1 (0.56) MAPTNPSR1HSPB1L3MBTL1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2488493-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. Hoffmann-La Roche AG (CH) 2012-08-22 EP disclosed
WO-2011045292-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. HOFFMANN-LA ROCHE AG (CH) 2011-04-21 WO disclosed