Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968361 | 0.94 | ALDH1A1 (0.48) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL3967036 | 0.92 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL3963572 | 0.92 | NPC1 (0.45) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL4237951 | 0.91 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL3966991 | 0.88 | KDM4E (0.42) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL3965796 | 0.88 | ALDH1A1 (0.39) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL3971989 | 0.88 | MAPT (0.42) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL3966907 | 0.88 | ALDH1A1 (0.41) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL3967905 | 0.88 | ALDH1A1 (0.39) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT | |
| SCHEMBL1161660 | 0.88 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1KDM4EFFAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220590-A1 | NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS | KAROBIOAB (SE) | 2012-08-30 | — | — | US | disclosed |
| EP-2459524-A2 | NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS | Cadila Healthcare Limited (IN) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011016050-A2 | NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS | CADILA HEALTHCARE LIMITED (IN) | 2011-02-10 | — | — | WO | disclosed |
| EP-1363876-B1 | GLUCOCORTICOID RECEPTOR MODULATORS | KAROBIO AB (SE) | 2009-07-29 | — | — | EP | disclosed |
| US-6583180-B2 | Antidiabetic agents | ABBOTT LABORATORIES | 2003-06-24 | — | — | US | disclosed |
| US-20020156311-A1 | Glucocorticoid receptor modulators | KARO BIO AB (SE) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156311-A1 | Glucocorticoid receptor modulators | NR3C1, NR5A1, NR3C2 | L3MBTL1 3445/4885ALDH1A1 1310/4885KDM4E 4102/4885 |
| US-20120220590-A1 | NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS | NR3C1, NR3C2, MC2R | L3MBTL1 4855/4885ALDH1A1 2679/4885KDM4E 3542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.