Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11784439 | 0.93 | CHRNA7 (0.56) | CHRNA7HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL11787894 | 0.86 | CHRNA7 (0.52) | TLR9CHRNA7ALDH1A1HTTHTR2A | |
| SCHEMBL11228025 | 0.86 | SIGMAR1 (0.59) | CHRNA7TSHR | |
| SCHEMBL11359930 | 0.84 | PARP1 (0.53) | TSHRDRD2 | |
| SCHEMBL26508424 | 0.81 | HTR2A (0.68) | CHRNA7ALDH1A1TSHRHTTHTR2A | |
| SCHEMBL11338350 | 0.80 | CHRNA7 (0.50) | TLR9CHRNA7HTR2AHTR2CDRD2 | |
| SCHEMBL11244654 | 0.80 | SIGMAR1 (0.54) | CHRNA7ALDH1A1TSHRHTT | |
| SCHEMBL11326948 | 0.80 | CHRNA7 (0.50) | TLR9CHRNA7HTR2AHTR2CDRD2 | |
| SCHEMBL28788491 | 0.79 | HTT (0.56) | ALDH1A1TSHRHTTHTR2AHTR2C | |
| SCHEMBL11619083 | 0.79 | DRD2 (0.62) | HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4110459-A | ANALGESIC | AMERICAN HOECHST CORPORATION (US) | 1978-08-29 | — | — | US | disclosed |
| US-4101663-A | ANTIHYPERTENSIVES | AMERICAN HOECHST CORPORATION (US) | 1978-07-18 | — | — | US | disclosed |
| US-4046900-A | TRANQUILIZERS, HYPOTENSIVES, ANALGESICS | AMERICAN HOECHST CORPORATION (US) | 1977-09-06 | — | — | US | disclosed |