Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777471 | 0.90 | NPC1 (0.49) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL466590 | 0.88 | NPC1 (0.47) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL9183011 | 0.86 | NPC1 (0.58) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL11428352 | 0.83 | NPC1 (0.51) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL15625194 | 0.82 | TYR (0.49) | LMNATYRALDH1A1TSHRNPSR1 | |
| SCHEMBL11615531 | 0.82 | NPC1 (0.50) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL11616092 | 0.82 | NPC1 (0.64) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL574153 | 0.82 | NPC1 (0.46) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL9468024 | 0.81 | NPC1 (0.41) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL3830756 | 0.80 | NPC1 (0.45) | NPC1RAB9ALMNAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4127586-A | HYDROXYPHENYL BENZOTRIAZOLES | CIBA-GEIGY CORPORATION (US) | 1978-11-28 | — | — | US | disclosed |