Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11754729 | 0.98 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL11447572 | 0.91 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| Phenylpiperazine SCHEMBL11447228 | 0.89 | HTR3E (0.57) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| SCHEMBL1100438 | 0.85 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| SCHEMBL11621545 | 0.84 | MAPT (0.56) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| SCHEMBL11162348 | 0.83 | ADRA2A (0.69) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| SCHEMBL520715 | 0.83 | MAPT (0.62) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| SCHEMBL519214 | 0.83 | MAPT (0.62) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| SCHEMBL519213 | 0.83 | MAPT (0.62) | ALDH1A1L3MBTL1ADRA2AADRA2BADRA2C | |
| SCHEMBL11622944 | 0.83 | MAPT (0.58) | KDM4EGFERKMT2AMAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1044365-C | Alpha, omega-diarylalkane derivatives, their preparation and their use in the treatment and prevention of circulatory diseases and psychosis | SANKYO CO (JP) | 1999-07-28 | — | — | CN | disclosed |
| CN-1187128-A | Phenoxy piperazine derivatives for treating disorders of dopamine system | HOFFMANN LA ROCHE (CH) | 1998-07-08 | — | — | CN | disclosed |
| US-4067982-A | LOWERING BLOOD PRESSURE, ANALGESIC, SEDATIVE, ANTIHISTAMINE | Gulden, Byk (DT) | 1978-01-10 | — | — | US | disclosed |
| US-3957786-A | HYPOTENSIVE AGENTS | BYK GULDEN (DT) | 1976-05-18 | — | — | US | disclosed |