Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 2/20 | 0.50 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8850768 | 0.88 | PDK2 (0.42) | CYP26A1CYP26B1AKR1B1GAAALDH1A1 | |
| SCHEMBL6146899 | 0.82 | CYP26A1 (0.69) | CYP26A1CYP26B1AKR1B1RXRARXRB | |
| SCHEMBL28840697 | 0.81 | CYP26A1 (0.51) | CYP26A1CYP26B1AKR1B1GAAALDH1A1 | |
| SCHEMBL6146444 | 0.79 | CYP26A1 (0.50) | CYP26A1CYP26B1AKR1B1GAAALDH1A1 | |
| SCHEMBL30148890 | 0.77 | CYP26A1 (0.48) | CYP26A1CYP26B1AKR1B1GAAALDH1A1 | |
| SCHEMBL27798527 | 0.76 | KMT2A (0.42) | GAAALDH1A1TDP1RAB9ACA2 | |
| SCHEMBL1346812 | 0.75 | PTGS2 (0.58) | AKR1B1PTGS1AKR1C3AKR1C2TSHR | |
| SCHEMBL27891996 | 0.74 | KDM4E (0.41) | GAAALDH1A1RAB9A | |
| SCHEMBL17316518 | 0.73 | CYP26A1 (0.52) | CYP26A1CYP26B1GAAALDH1A1PTGS1 | |
| SCHEMBL28953081 | 0.72 | CYP26A1 (0.46) | CYP26A1CYP26B1AKR1B1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778970-B2 | Benzyl piperidine compound | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2014-07-15 | — | — | US | disclosed |
| US-20130303786-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO (JP) | 2013-11-14 | — | — | US | disclosed |
| US-8557998-B2 | Benzylpiperizine compound | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2013-10-15 | — | — | US | disclosed |
| US-20120259122-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-10-11 | — | — | US | disclosed |
| US-8232405-B2 | Benzylpiperizine compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-31 | — | — | US | disclosed |
| EP-2463286-A1 | BENZYL PIPERIDINE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-06-13 | — | — | EP | disclosed |
| US-20120130077-A1 | BENZYL PIPERIDINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-05-24 | — | — | US | disclosed |
| WO-2011016468-A1 | BENZYL PIPERIDINE COMPOUND | 大日本住友製薬株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |
| EP-2239254-A1 | BENZYLPIPERIZINE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009099087-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130077-A1 | BENZYL PIPERIDINE COMPOUND | HTR1D, HTR1A, HTR1B | CYP26A1 968/4885CYP26B1 1568/4885AKR1B1 2306/4885 |
| US-20130303786-A1 | BENZYLPIPERIZINE COMPOUND | OPRM1, GRM1, CHRM1 | CYP26A1 535/4885CYP26B1 562/4885AKR1B1 1228/4885 |
| US-20120259122-A1 | BENZYLPIPERIZINE COMPOUND | OPRM1, GRM1, CHRM1 | CYP26A1 535/4885CYP26B1 562/4885AKR1B1 1228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.