Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.50 |
| ▸ | GABRE | P78334 | 1/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.50 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.50 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.50 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543348 | 0.84 | ADORA3 (0.61) | ADORA3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11545228 | 0.81 | GABRP (0.49) | ADORA3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11547087 | 0.75 | ADORA3 (0.60) | ADORA3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11543017 | 0.71 | PBRM1 (0.48) | ADORA3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28313337 | 0.71 | HAVCR2 (0.51) | ADORA3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11544213 | 0.71 | GABRP (0.50) | ADORA3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11543165 | 0.69 | ADORA3 (0.60) | ADORA3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11258739 | 0.69 | ADORA3 (0.74) | ADORA3 | |
| SCHEMBL11084193 | 0.69 | GABRP (0.64) | ADORA3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL17559719 | 0.68 | MEN1 (0.65) | KDM4EALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4123532-A | ADMINISTERING A PYRAZOLO(1,5-C)QUINAZOLIN-5(6H)-ONE COMPOUND | E. R. SQUIBB & SONS, INC. (US) | 1978-10-31 | — | — | US | disclosed |