Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.34 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233921 | 1.00 | MAPT (0.36) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL141511 | 1.00 | MAPT (0.36) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL12219484 | 0.91 | MAPT (0.36) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL6241158 | 0.89 | NPSR1 (0.36) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL6241154 | 0.89 | NPSR1 (0.36) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL9145727 | 0.88 | MAPT (0.39) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL9145729 | 0.88 | MAPT (0.39) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL23298400 | 0.87 | MAPT (0.36) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL12752723 | 0.87 | MAPT (0.36) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL9149987 | 0.87 | MAPT (0.35) | MAPTKMT2AMEN1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-8039485-B2 | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid | WARNER CHILCOTT COMPANY, LLC (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| US-7528264-B2 | Hydride reduction process for preparing quinolone intermediates | THE PROCTER & GAMBLE COMPANY (US) | 2009-05-05 | — | — | US | disclosed |
| US-7456279-B2 | Coupling process for preparing quinolone intermediates | THE PROCTER & GAMBLE COMPANY (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070232650-A1 | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid | THE PROCTER & GAMBLE COMPANY | 2007-10-04 | — | — | US | disclosed |
| US-20070232806-A1 | Hydride reduction process for preparing quinolone intermediates | THE PROCTER & GAMBLE COMPANY (US) | 2007-10-04 | — | — | US | disclosed |
| US-20070232804-A1 | Coupling process for preparing quinolone intermediates | THE PROCTER & GAMBLE COMPANY (US) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232804-A1 | Coupling process for preparing quinolone intermediates | CYP3A4, CYP4B1, CYP4X1 | MAPT 4271/4885KMT2A 2928/4885MEN1 1363/4885 |
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | RECQL, BLVRB, NQO2 | MAPT 4835/4885KMT2A 4780/4885MEN1 3668/4885 |
| US-20070232650-A1 | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid | SLC25A11, MDH2, MDH1 | MAPT 1783/4885KMT2A 2561/4885MEN1 1184/4885 |
| US-20070232806-A1 | Hydride reduction process for preparing quinolone intermediates | NQO1, NQO2, POR | MAPT 4381/4885KMT2A 1279/4885MEN1 1566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.