Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11633252 | 0.97 | MAPT (0.56) | MAPTKMT2AHTTMEN1LMNA | |
| Bromide SCHEMBL11633217 | 0.85 | INSR (0.56) | MAPTKMT2AHTTMEN1LMNA | |
| Hydrochloric Acid SCHEMBL11629281 | 0.85 | INSR (0.46) | MAPTKMT2AHTTMEN1LMNA | |
| Iodide SCHEMBL11635184 | 0.82 | INSR (0.56) | MAPTKMT2AHTTMEN1LMNA | |
| Hydrochloric Acid SCHEMBL11632202 | 0.82 | INSR (0.56) | MAPTKMT2AHTTMEN1LMNA | |
| Bromide SCHEMBL11630617 | 0.80 | ADRB2 (0.50) | MAPTKMT2AHTTMEN1LMNA | |
| SCHEMBL16791401 | 0.79 | MAPT (0.57) | MAPTKMT2AHTTMEN1LMNA | |
| SCHEMBL8080557 | 0.78 | MAPT (0.69) | MAPTKMT2AHTTMEN1LMNA | |
| SCHEMBL13046317 | 0.78 | MAPT (0.69) | MAPTKMT2AHTTMEN1LMNA | |
| SCHEMBL8080554 | 0.78 | MAPT (0.69) | MAPTKMT2AHTTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4085112-A | 2-Formyl-3-alkyl-benzothiazolium halide oxime | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1978-04-18 | — | — | US | disclosed |