SCHEMBL1162822

SCHEMBL1162822

C=C(C(=O)O)c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 2/20 0.60
SRD5A2 P31213 6/20 0.58
ERCC5 P28715 1/20 0.56
FEN1 P39748 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.49
PGR P06401 1/20 0.49
AKR1C3 P42330 1/20 0.48
LTA4H P09960 2/20 0.48
NR1H2 P55055 1/20 0.48
BAX Q07812 1/20 0.48
TSHR P16473 1/20 0.48
ALDH1A1 P00352 2/20 0.47
MMP1 P03956 1/20 0.47
NPC1 O15118 1/20 0.47
POLB P06746 1/20 0.47
HSP90AA1 P07900 1/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47
PARP15 Q460N3 1/20 0.47
PARP14 Q460N5 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9865063 0.85 PARP10 (0.67) PARP10SRD5A2ERCC5FEN1SMN1; SMN2
SCHEMBL10764118 0.85 PARP10 (0.56) PARP10SRD5A2ERCC5FEN1SMN1; SMN2
SCHEMBL8897038 0.82 PARP10 (0.53) PARP10SRD5A2ERCC5FEN1SMN1; SMN2
SCHEMBL7319763 0.81 PARP10 (0.65) PARP10
SCHEMBL28800035 0.81 PARP10 (0.56) PARP10SRD5A2ERCC5FEN1SMN1; SMN2
SCHEMBL44226 0.80 CES1 (0.52) ERCC5FEN1SMN1; SMN2TSHRALDH1A1
SCHEMBL713716 0.80 TSHR (0.47) SRD5A2SMN1; SMN2TSHRALDH1A1
SCHEMBL5422096 0.79 PARP10 (0.70) PARP10SRD5A2ERCC5FEN1SMN1; SMN2
SCHEMBL4166171 0.79 PARP10 (0.64) PARP10SRD5A2ERCC5FEN1PGR
Dimethylamine SCHEMBL9864604 0.79 PARP10 (0.59) PARP10SRD5A2ERCC5FEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2464647-A1 AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF Bristol-Myers Squibb Company (US) 2012-06-20 EP disclosed
WO-2011019780-A1 AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2011-02-17 WO disclosed