SCHEMBL4166171

SCHEMBL4166171

O=C(O)C(=O)c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 1/20 0.64
SRD5A2 P31213 4/20 0.62
PTPRC P08575 4/20 0.59
PTPN1 P18031 4/20 0.59
ERCC5 P28715 1/20 0.59
FEN1 P39748 1/20 0.59
CES2 O00748 2/20 0.53
CES1 P23141 2/20 0.53
PTPN2 P17706 1/20 0.53
LTA4H P09960 2/20 0.52
TSHR P16473 1/20 0.52
CPT1B Q92523 1/20 0.52
NR1H2 P55055 1/20 0.52
BAX Q07812 1/20 0.52
AKR1C3 P42330 1/20 0.52
PGR P06401 1/20 0.52
PTPRF P10586 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4189871 0.91 PARP10 (0.69) PARP10SRD5A2ERCC5FEN1CES2
SCHEMBL9043928 0.89 PKM (0.66) PARP10SRD5A2PTPRCPTPN1ERCC5
SCHEMBL9242631 0.89 CES2 (0.68) PARP10SRD5A2ERCC5FEN1CES2
SCHEMBL9807208 0.87 PARP10 (0.64) PARP10SRD5A2ERCC5FEN1CES2
SCHEMBL2134251 0.86 CES2 (0.71) PARP10SRD5A2ERCC5FEN1CES2
SCHEMBL13567254 0.86 CES2 (0.71) PARP10SRD5A2ERCC5FEN1CES2
SCHEMBL9250736 0.86 CES2 (0.71) PARP10SRD5A2ERCC5FEN1CES2
SCHEMBL28800035 0.84 PARP10 (0.56) PARP10SRD5A2ERCC5FEN1CES2
SCHEMBL15059492 0.83 PARP10 (0.60) PARP10SRD5A2ERCC5FEN1CES2
SCHEMBL8366994 0.83 PARP10 (0.60) PARP10SRD5A2ERCC5FEN1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115403459-A Preparation method of 1, 4-dicarbonyl compound 广州自远生物科技有限公司 2022-11-29 CN disclosed
US-20100022676-A1 PHOTOCURABLE COMPOSITIONS COMPRISING A PHOTOINITIATOR OF THE PHENYLGLYOXYLATE TYPE CIBA CORPORATION 2010-01-28 US disclosed
US-20090075989-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS BAYER SCHERING PHARMA AG (DE) 2009-03-19 US disclosed
US-20090075989-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS BAYER SCHERING PHARMA AG (DE) 2009-03-19 US disclosed
US-20090075989-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS BAYER SCHERING PHARMA AG (DE) 2009-03-19 US disclosed
US-7396488-B2 Light emitting device and fluorescent material MITSUBISHI CHEMICAL CORPORATION (JP) 2008-07-08 US disclosed
US-7396488-B2 Light emitting device and fluorescent material MITSUBISHI CHEMICAL CORPORATION (JP) 2008-07-08 US disclosed
WO-2008077646-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-07-03 WO disclosed
WO-2008077646-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-07-03 WO disclosed
WO-2008040650-A2 PHOTOCURABLE COMPOSITIONS COMPRISING A PHOTOINITIATOR OF THE PHENYLGLYOXYLATE TYPE CIBA HOLDING INC. (CH) 2008-04-10 WO disclosed
CN-1244666-C Fluorescent maleimides and uses thereof CIBA SC HOLDING AG (CH) 2006-03-08 CN disclosed
CN-1721498-A Fluorescent maleimides and uses thereof CIBA SC HOLDING AG (CH) 2006-01-18 CN disclosed
US-6960667-B2 Fluorescent maleimides and uses thereof CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-11-01 US disclosed
US-20030189191-A1 Fluorescent maleimides and uses thereof KUNIMOTO KAZUHIKO (JP) 2003-10-09 US disclosed
US-6508957-B2 Ultraviolet fluorescent material for void detection and for preparation of scintillators, films, luminescent solar energy collectors, organic electroluminescent devices, printing inks, electrophotographic toners CIBA SPECIALTY CHEMICALS CORPORATION 2003-01-21 US disclosed
CN-1374995-A Fluorescent maleimides and uses thereof CIBA SC HOLDING AG (CH) 2002-10-16 CN disclosed
EP-1216285-A1 FLUORESCENT MALEIMIDES AND USES THEREOF Ciba SC Holding AG (CH) 2002-06-26 EP disclosed
US-20020065422-A1 Fluorescent maleimides and uses thereof KUNIMOTO KAZUHIKO (JP) 2002-05-30 US disclosed
US-6258954-B1 ELECTROLUMINESCENCE; DETECTION VOIDS CIBA SPECIALTY CHEMICALS CORP. 2001-07-10 US disclosed
WO-2001019939-A1 FLUORESCENT MALEIMIDES AND USES THEREOF CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2001-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020065422-A1 Fluorescent maleimides and uses thereof IK, PAH, MYO1F PARP10 1103/4885SRD5A2 367/4885PTPRC 1951/4885
US-20030189191-A1 Fluorescent maleimides and uses thereof CBR1, CBR3, MT-CO2 PARP10 1435/4885SRD5A2 508/4885PTPRC 2664/4885
US-20100022676-A1 PHOTOCURABLE COMPOSITIONS COMPRISING A PHOTOINITIATOR OF THE PHENYLGLYOXYLATE TYPE GLO1, HPD, GRHPR PARP10 497/4885SRD5A2 3152/4885PTPRC 3186/4885
US-20090075989-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS NR5A1, CYP19A1, GPER1 PARP10 1431/4885SRD5A2 27/4885PTPRC 2383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.