Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 7/20 | 0.40 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.40 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11630782 | 1.00 | S1PR1 (0.40) | S1PR1TNNC1S1PR4S1PR3S1PR5 | |
| SCHEMBL4861420 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL5715855 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL3059895 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL4849476 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL23302194 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL2338285 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL187351 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL4190029 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL31307196 | 0.84 | THRB (0.44) | MEN1KMT2ATHRBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4087597-A | Anti-fouling compositions | BIOMARINE HANDELSGESELLSCHAFT AG. (FL) | 1978-05-02 | — | — | US | disclosed |