Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11301329 | 0.83 | — | — | |
| SCHEMBL11630880 | 0.79 | CYP2D6 (0.32) | — | |
| SCHEMBL11631073 | 0.76 | LMNA (0.34) | — | |
| SCHEMBL13483446 | 0.76 | — | — | |
| SCHEMBL9644041 | 0.72 | — | — | |
| SCHEMBL6278550 | 0.72 | — | — | |
| SCHEMBL24853684 | 0.72 | CHRM2 (0.46) | EZH2 | |
| SCHEMBL21430658 | 0.72 | CHRM2 (0.46) | EZH2 | |
| SCHEMBL12259026 | 0.72 | CHRM2 (0.46) | EZH2 | |
| SCHEMBL441973 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989434-B2 | Heterocyclic self-immolative linkers and conjugates | SEATTLE GENETICS, INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100273843-A1 | HETEROCYCLIC SELF-IMMOLATIVE LINKERS AND CONJUGATES | SEAGEN INC. | 2010-10-28 | — | — | US | disclosed |
| US-7754681-B2 | Heterocyclic self-immolative linkers and conjugates | SEATTLE GENETICS, INC. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20090041791-A1 | Heterocyclic self-immolative Linkers and Conjugates | SEAGEN INC. | 2009-02-12 | — | — | US | disclosed |
| US-7375078-B2 | Heterocyclic self-immolative linkers and conjugates | GENENTECH, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-4113464-A | HERBICIDES | VELSICOL CHEMICAL COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090041791-A1 | Heterocyclic self-immolative Linkers and Conjugates | CTSL, DNPEP, CTSE | HTR2C 3691/4885EZH2 4516/4885ADRB2 4666/4885 |
| US-20100273843-A1 | HETEROCYCLIC SELF-IMMOLATIVE LINKERS AND CONJUGATES | CTSL, DNPEP, CTSE | HTR2C 3691/4885EZH2 4516/4885ADRB2 4666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.