CTSE — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Dolastatin 15 (SCHEMBL187502)	0.36	10/20
Symplostatin 3 (SCHEMBL1344454)	0.34	10/20
SCHEMBL1687437	0.38	7/20
SCHEMBL1687443	0.35	6/20
Dolastatin-10 (SCHEMBL5286)	0.32	6/20
Symplostatin 1 (SCHEMBL1344834)	0.32	6/20
SCHEMBL1687439	0.31	6/20
SCHEMBL2353525	0.66	4/20
SCHEMBL2351551	0.65	4/20
SCHEMBL2352364	0.65	4/20
SCHEMBL2354066	0.65	4/20
SCHEMBL2355050	0.65	4/20
SCHEMBL2349979	0.64	4/20
SCHEMBL2354052	0.64	4/20
SCHEMBL2349597	0.62	4/20
SCHEMBL2350865	0.54	4/20
SCHEMBL2356431	0.53	4/20
SCHEMBL2346945	0.43	4/20
SCHEMBL2346950	0.43	4/20
SCHEMBL719403	0.67	3/20

Clinical trials — most relevant to CTSE by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19	PHASE2/PHASE3	UNKNOWN
DEFINE - Evaluating Therapies for COVID-19	PHASE1/PHASE2	COMPLETED
A Phase I/II Clinical Study of CTS3497 in Patients With MTAP Deficient Malignacies	PHASE1/PHASE2	RECRUITING
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis	PHASE1/PHASE2	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis	nan	COMPLETED
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD	nan	NOT_YET_RECRUITING
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome	nan	RECRUITING
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients	nan	RECRUITING
Synovial Fluid Bank From Arthritic Patients	nan	RECRUITING
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery	nan	RECRUITING
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Proteases in Patients With Prostate Cancer That Has Spread to the Bone	nan	COMPLETED
Validation of New Therapeutic Targets to Prevent Collagen Accumulation During Cardiac Fibrosis: Procollagen C-proteinase Enhancers	nan	COMPLETED
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Association Between Periodontitis and Coronavirus Disease (COVID-19)	nan	COMPLETED
New Imaging Technology to Assess Effect of Enzyme Replacment Therapy on Eye Disease Progession in Mucopolysacchardiosis	nan	UNKNOWN
Fasting, Exercise, and Diet to Activate Autophagy in Depression	nan	NOT_YET_RECRUITING
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Pathophysiology of Paget's Disease of Bone	nan	COMPLETED
Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery	nan	COMPLETED
Intraneural Facilitation as a Treatment for Carpal Tunnel Syndrome	nan	COMPLETED
Diagnosis of Carpal Tunnel Syndrome: Effectiveness of Diagnostic Tests. Clinical Trial of Accuracy	nan	COMPLETED
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE

Related proteins — ESM-2 sequence neighbours (a CTSE binder may also engage these)

Protein	Name	Similarity
P16228	—	0.999	P16228 →
P25796	—	0.997	P25796 →
P70269	—	0.997	P70269 →
P16476	—	0.995	P16476 →
P43159	—	0.992	P43159 →
Q9N2D2	—	0.988	Q9N2D2 →
Q9D7R7	—	0.985	Q9D7R7 →
Q9N2D3	—	0.982	Q9N2D3 →
P18276	—	0.982	P18276 →
Q9GMY4	—	0.981	Q9GMY4 →
P04073	—	0.980	P04073 →
P00793	—	0.980	P00793 →
Q9GMY8	—	0.980	Q9GMY8 →
P27678	—	0.980	P27678 →
Q805F3	—	0.980	Q805F3 →
O93428	—	0.980	O93428 →
PGC	Gastricsin	0.979	landscape →
PGA5	Pepsin A	0.979	landscape →
P00794	—	0.978	P00794 →
P0DJD8	—	0.978	P0DJD8 →
P28712	—	0.977	P28712 →
Q9N2D4	—	0.976	Q9N2D4 →
Q805F2	—	0.976	Q805F2 →
Q9GK11	—	0.975	Q9GK11 →
Q9DEX3	—	0.975	Q9DEX3 →
Q9GMY6	—	0.974	Q9GMY6 →
Q9D106	—	0.974	Q9D106 →
Q4LAL9	—	0.974	Q4LAL9 →
P0DJD7	—	0.974	P0DJD7 →
Q64411	—	0.974	Q64411 →