Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.64 |
| ▸ | CNR2 | P34972 | 3/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163452 | 0.84 | MGAM (0.61) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| Quinaldic Acid SCHEMBL29350584 | 0.78 | MGAM (1.00) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| Quinaldic Acid SCHEMBL39024 | 0.78 | MGAM (1.00) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| SCHEMBL4596660 | 0.78 | MGAM (0.64) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| SCHEMBL12256867 | 0.78 | MGAM (0.64) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| SCHEMBL31028622 | 0.78 | MGAM (0.64) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| Quinaldic Acid SCHEMBL1242670 | 0.78 | MGAM (1.00) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| SCHEMBL1163226 | 0.78 | MGAM (0.53) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| Quinaldic Acid SCHEMBL4802724 | 0.77 | MGAM (0.96) | MGAMCNR2HDAC8SMN1; SMN2RAB9A | |
| Quinaldic Acid SCHEMBL2372429 | 0.77 | MGAM (0.96) | MGAMCNR2HDAC8SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497368-B2 | Heterocyclic hydrazone compounds | NOVARTIS AG (CH) | 2013-07-30 | — | — | US | disclosed |
| EP-2464649-A1 | HETEROCYCLIC HYDRAZONE COMPOUNDS AND THEIR USES TO TREAT CANCER AND INFLAMMATION | Novartis AG (CH) | 2012-06-20 | — | — | EP | disclosed |
| US-20120142681-A1 | HETEROCYCLIC HYDRAZONE COMPOUNDS | NOVARTIS AG (CH) | 2012-06-07 | — | — | US | disclosed |
| WO-2011018454-A1 | HETEROCYCLIC HYDRAZONE COMPOUNDS AND THEIR USES TO TREAT CANCER AND INFLAMMATION | NOVARTIS AG (CH) | 2011-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142681-A1 | HETEROCYCLIC HYDRAZONE COMPOUNDS | MET, HGF, RET | MGAM 3430/4885CNR2 775/4885HDAC8 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.