Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 19/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163738 | 0.88 | PTK2 (0.67) | PTK2EGFR | |
| SCHEMBL20420601 | 0.86 | PTK2 (0.49) | PTK2 | |
| SCHEMBL16995419 | 0.82 | PTK2 (0.53) | PTK2 | |
| SCHEMBL380932 | 0.81 | PTK2 (0.52) | PTK2 | |
| SCHEMBL1164034 | 0.79 | PTK2 (0.83) | PTK2 | |
| SCHEMBL12119496 | 0.75 | LRRK2 (0.48) | PTK2 | |
| SCHEMBL12745482 | 0.74 | LRRK2 (0.51) | PTK2 | |
| SCHEMBL1466613 | 0.74 | LRRK2 (0.51) | PTK2 | |
| SCHEMBL1467078 | 0.74 | LRRK2 (0.51) | PTK2 | |
| SCHEMBL12745485 | 0.74 | LRRK2 (0.51) | PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464634-B1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2016-11-30 | — | — | EP | disclosed |
| US-8933227-B2 | Selective synthesis of functionalized pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-01-13 | — | — | US | disclosed |
| EP-2464634-A1 | REGIOSELECTIVE PREPARATION OF 2 -AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2012-06-20 | — | — | EP | disclosed |
| US-20110190499-A1 | SELECTIVE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-04 | — | — | US | disclosed |
| WO-2011018518-A1 | REGIOSELECTIVE PREPARATION OF 2 -AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190499-A1 | SELECTIVE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES | DPYD, TYMS, UMPS | PTK2 3914/4885EGFR 2285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.